TY - GEN
T1 - Sensitivity analysis for small imaging domains using the frequency-domain transport equation
AU - Gu, Xuejun
AU - Ren, Kui
AU - Hielscher, Andreas H.
PY - 2007
Y1 - 2007
N2 - Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.
AB - Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.
KW - Equation of radiative transfer
KW - Finite volume method
KW - Optical tomography
KW - Signal-to-noise
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U2 - 10.1117/12.728584
DO - 10.1117/12.728584
M3 - Conference contribution
AN - SCOPUS:85088341487
SN - 9780819467713
T3 - Optics InfoBase Conference Papers
BT - European Conference on Biomedical Optics, ECBO 2007
PB - Optical Society of America (OSA)
T2 - European Conference on Biomedical Optics, ECBO 2007
Y2 - 17 June 2007 through 17 June 2007
ER -