Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells

Stephen Li; Dileep Karri; Efrain Sanchez-Ortiz; Priscilla Jaichander; Rhonda Bassel-Duby; Ning Liu; Eric N. Olson

doi:10.1016/j.devcel.2019.08.002

Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2⁺ Cells

Stephen Li, Dileep Karri, Efrain Sanchez-Ortiz, Priscilla Jaichander, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Tw2⁺ cells are an interstitial muscle progenitor population that fuses specifically with fast-twitch myofibers. Li et al. show that the mechanism of fiber-type specificity revolves around a chemorepulsion system mediated by Sema3a and Nrp1 signaling.

Original language	English (US)
Pages (from-to)	89-98.e4
Journal	Developmental cell
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2019.08.002
State	Published - Oct 7 2019

Keywords

Twist2
chemorepulsion
fiber-type specificity
fusion
muscle stem cell
plexin
semaphorin
stripe assay

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

Access to Document

10.1016/j.devcel.2019.08.002

Cite this

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title = "Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells",

abstract = "Tw2+ cells are an interstitial muscle progenitor population that fuses specifically with fast-twitch myofibers. Li et al. show that the mechanism of fiber-type specificity revolves around a chemorepulsion system mediated by Sema3a and Nrp1 signaling.",

keywords = "Twist2, chemorepulsion, fiber-type specificity, fusion, muscle stem cell, plexin, semaphorin, stripe assay",

author = "Stephen Li and Dileep Karri and Efrain Sanchez-Ortiz and Priscilla Jaichander and Rhonda Bassel-Duby and Ning Liu and Olson, {Eric N.}",

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AU - Li, Stephen

AU - Karri, Dileep

AU - Sanchez-Ortiz, Efrain

AU - Jaichander, Priscilla

AU - Bassel-Duby, Rhonda

AU - Liu, Ning

AU - Olson, Eric N.

PY - 2019/10/7

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KW - chemorepulsion

KW - fiber-type specificity

KW - fusion

KW - muscle stem cell

KW - plexin

KW - semaphorin

KW - stripe assay

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