Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells

Stephen Li, Dileep Karri, Efrain Sanchez-Ortiz, Priscilla Jaichander, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Tw2+ cells are an interstitial muscle progenitor population that fuses specifically with fast-twitch myofibers. Li et al. show that the mechanism of fiber-type specificity revolves around a chemorepulsion system mediated by Sema3a and Nrp1 signaling.

Original languageEnglish (US)
Pages (from-to)89-98.e4
JournalDevelopmental cell
Issue number1
StatePublished - Oct 7 2019


  • Twist2
  • chemorepulsion
  • fiber-type specificity
  • fusion
  • muscle stem cell
  • plexin
  • semaphorin
  • stripe assay

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


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