TY - JOUR
T1 - Self-reported depression and anti-depressant medication use in essential tremor
T2 - Cross-sectional and prospective analyses in a population-based study
AU - Louis, E. D.
AU - Benito-León, J.
AU - Bermejo-Pareja, F.
PY - 2007/10
Y1 - 2007/10
N2 - There are few data on the co-morbidity of essential tremor (ET) with depression. To assess the associations of ET with self-reported depression and antidepressant medication use. In a population-based study in central Spain, participants were evaluated at baseline (1994-1995) and 3 years later. Self-reported depression and use of antidepressant medications were evaluated at each assessment. In cross-sectional analyses, prevalent ET cases were twice more probably than controls to report depression [103 (43.8%) of 235 cases versus 1137 (26.0%) of 4379 controls; adjusted odds ratio (OR) 2.20, 95% confidence interval (CI) 1.66-2.93, P < 0.001] and three times more probably to be taking antidepressant medications [16 (6.8%) cases versus 113 (2.6%) controls; adjusted OR 3.33, 95% CI 1.91-5.82, P = 0.001]. In prospective analyses, baseline self-reported depression (adjusted RR 1.78, 95% CI 1.11-2.89, P = 0.018) and, perhaps, baseline use of antidepressant medication (adjusted RR 1.90, 95% CI 0.59-6.05, P = 0.28) were associated with incident ET. Rather than being totally benign, ET seems to be associated with a mood disorder. Furthermore, as well as being a secondary response to disease manifestations, this mood disorder may be a primary feature of the underlying disease.
AB - There are few data on the co-morbidity of essential tremor (ET) with depression. To assess the associations of ET with self-reported depression and antidepressant medication use. In a population-based study in central Spain, participants were evaluated at baseline (1994-1995) and 3 years later. Self-reported depression and use of antidepressant medications were evaluated at each assessment. In cross-sectional analyses, prevalent ET cases were twice more probably than controls to report depression [103 (43.8%) of 235 cases versus 1137 (26.0%) of 4379 controls; adjusted odds ratio (OR) 2.20, 95% confidence interval (CI) 1.66-2.93, P < 0.001] and three times more probably to be taking antidepressant medications [16 (6.8%) cases versus 113 (2.6%) controls; adjusted OR 3.33, 95% CI 1.91-5.82, P = 0.001]. In prospective analyses, baseline self-reported depression (adjusted RR 1.78, 95% CI 1.11-2.89, P = 0.018) and, perhaps, baseline use of antidepressant medication (adjusted RR 1.90, 95% CI 0.59-6.05, P = 0.28) were associated with incident ET. Rather than being totally benign, ET seems to be associated with a mood disorder. Furthermore, as well as being a secondary response to disease manifestations, this mood disorder may be a primary feature of the underlying disease.
KW - Antidepressant
KW - Clinical manifestations
KW - Depression
KW - Epidemiology
KW - Essential tremor
KW - Psychiatry
UR - http://www.scopus.com/inward/record.url?scp=34648813094&partnerID=8YFLogxK
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U2 - 10.1111/j.1468-1331.2007.01923.x
DO - 10.1111/j.1468-1331.2007.01923.x
M3 - Article
C2 - 17708753
AN - SCOPUS:34648813094
SN - 1351-5101
VL - 14
SP - 1138
EP - 1146
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 10
ER -