Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

Roy N. Alcalay; Helen Mejia-Santana; Ming X. Tang; Brian Rakitin; Llency Rosado; Barbara Ross; Miguel Verbitsky; Sergey Kisselev; Elan D. Louis; Cynthia L. Comella; Amy Colcher; Danna Jennings; Martha A. Nance; Susan Bressman; William K. Scott; Caroline Tanner; Susan F. Mickel; Howard F. Andrews; Cheryl H. Waters; Stanley Fahn; Lucien J. Cote; Steven J. Frucht; Blair Ford; Michael Rezak; Kevin Novak; Joseph H. Friedman; Ronald Pfeiffer; Laura Marsh; Bradley Hiner; Andrew Siderowf; Ruth Ottman; Lorraine N. Clark; Karen S. Marder; Elise Caccappolo

doi:10.1080/13803390903521018

Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

Roy N. Alcalay, Helen Mejia-Santana, Ming X. Tang, Brian Rakitin, Llency Rosado, Barbara Ross, Miguel Verbitsky, Sergey Kisselev, Elan D. Louis, Cynthia L. Comella, Amy Colcher, Danna Jennings, Martha A. Nance, Susan Bressman, William K. Scott, Caroline Tanner, Susan F. Mickel, Howard F. Andrews, Cheryl H. Waters, Stanley FahnLucien J. Cote, Steven J. Frucht, Blair Ford, Michael Rezak, Kevin Novak, Joseph H. Friedman, Ronald Pfeiffer, Laura Marsh, Bradley Hiner, Andrew Siderowf, Ruth Ottman, Lorraine N. Clark, Karen S. Marder, Elise Caccappolo

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.

Original language	English (US)
Pages (from-to)	775-779
Number of pages	5
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	32
Issue number	7
DOIs	https://doi.org/10.1080/13803390903521018
State	Published - Aug 2010
Externally published	Yes

Keywords

Cognition
Genetics
Glucocerebrosidase
Leucine-rich repeat kinase-2
Mini-mental state examination
Parkin
Parkinson

ASJC Scopus subject areas

Clinical Neurology
Neuropsychology and Physiological Psychology
Neurology
Clinical Psychology

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10.1080/13803390903521018

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Alcalay, R. N., Mejia-Santana, H., Tang, M. X., Rakitin, B., Rosado, L., Ross, B., Verbitsky, M., Kisselev, S., Louis, E. D., Comella, C. L., Colcher, A., Jennings, D., Nance, M. A., Bressman, S., Scott, W. K., Tanner, C., Mickel, S. F., Andrews, H. F., Waters, C. H., ... Caccappolo, E. (2010). Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 32(7), 775-779. https://doi.org/10.1080/13803390903521018

Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease. / Alcalay, Roy N.; Mejia-Santana, Helen; Tang, Ming X. et al.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 32, No. 7, 08.2010, p. 775-779.

Research output: Contribution to journal › Article › peer-review

Alcalay, RN, Mejia-Santana, H, Tang, MX, Rakitin, B, Rosado, L, Ross, B, Verbitsky, M, Kisselev, S, Louis, ED, Comella, CL, Colcher, A, Jennings, D, Nance, MA, Bressman, S, Scott, WK, Tanner, C, Mickel, SF, Andrews, HF, Waters, CH, Fahn, S, Cote, LJ, Frucht, SJ, Ford, B, Rezak, M, Novak, K, Friedman, JH, Pfeiffer, R, Marsh, L, Hiner, B, Siderowf, A, Ottman, R, Clark, LN, Marder, KS & Caccappolo, E 2010, 'Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease', Journal of Clinical and Experimental Neuropsychology, vol. 32, no. 7, pp. 775-779. https://doi.org/10.1080/13803390903521018

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title = "Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease",

abstract = "While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.",

keywords = "Cognition, Genetics, Glucocerebrosidase, Leucine-rich repeat kinase-2, Mini-mental state examination, Parkin, Parkinson",

author = "Alcalay, {Roy N.} and Helen Mejia-Santana and Tang, {Ming X.} and Brian Rakitin and Llency Rosado and Barbara Ross and Miguel Verbitsky and Sergey Kisselev and Louis, {Elan D.} and Comella, {Cynthia L.} and Amy Colcher and Danna Jennings and Nance, {Martha A.} and Susan Bressman and Scott, {William K.} and Caroline Tanner and Mickel, {Susan F.} and Andrews, {Howard F.} and Waters, {Cheryl H.} and Stanley Fahn and Cote, {Lucien J.} and Frucht, {Steven J.} and Blair Ford and Michael Rezak and Kevin Novak and Friedman, {Joseph H.} and Ronald Pfeiffer and Laura Marsh and Bradley Hiner and Andrew Siderowf and Ruth Ottman and Clark, {Lorraine N.} and Marder, {Karen S.} and Elise Caccappolo",

note = "Funding Information: This study was funded by NIH NS36630, UL1 RR024156 (K.S.M.), NS050487, NS060113 (L.N.C.), and the Parkinson{\textquoteright}s Disease Foundation (K.S.M., S.F., and L.N.C.). RNA was supported by a Parkinson{\textquoteright}s Disease Foundation H. Houston Merritt Fellowship in Movement Disorders. The authors thank Adam Brickman, Paul Greene, and Diana Ruiz for their assistance. Disclosure: The authors report no conflicts of interest.",

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AU - Alcalay, Roy N.

AU - Mejia-Santana, Helen

AU - Tang, Ming X.

AU - Rakitin, Brian

AU - Rosado, Llency

AU - Ross, Barbara

AU - Verbitsky, Miguel

AU - Kisselev, Sergey

AU - Louis, Elan D.

AU - Comella, Cynthia L.

AU - Colcher, Amy

AU - Jennings, Danna

AU - Nance, Martha A.

AU - Bressman, Susan

AU - Scott, William K.

AU - Tanner, Caroline

AU - Mickel, Susan F.

AU - Andrews, Howard F.

AU - Waters, Cheryl H.

AU - Fahn, Stanley

AU - Cote, Lucien J.

AU - Frucht, Steven J.

AU - Ford, Blair

AU - Rezak, Michael

AU - Novak, Kevin

AU - Friedman, Joseph H.

AU - Pfeiffer, Ronald

AU - Marsh, Laura

AU - Hiner, Bradley

AU - Siderowf, Andrew

AU - Ottman, Ruth

AU - Clark, Lorraine N.

AU - Marder, Karen S.

AU - Caccappolo, Elise

N1 - Funding Information: This study was funded by NIH NS36630, UL1 RR024156 (K.S.M.), NS050487, NS060113 (L.N.C.), and the Parkinson’s Disease Foundation (K.S.M., S.F., and L.N.C.). RNA was supported by a Parkinson’s Disease Foundation H. Houston Merritt Fellowship in Movement Disorders. The authors thank Adam Brickman, Paul Greene, and Diana Ruiz for their assistance. Disclosure: The authors report no conflicts of interest.

PY - 2010/8

Y1 - 2010/8

N2 - While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.

AB - While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.

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KW - Genetics

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KW - Leucine-rich repeat kinase-2

KW - Mini-mental state examination

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Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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