@article{f9dff23b7af042f9a3f63290ad398bf7,
title = "Selective modification of fluciclovine (18F) transport in prostate carcinoma xenografts",
abstract = "We investigated if previously demonstrated inhibition of fluciclovine (18F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (± 5.4)% and 25.3 (± 5.2)% lower in BCH (n = 6) and MeAIB (n = 5) injected PC3 Luc xenografts, respectively, compared to saline-injected controls (n = 2). Partial inhibition of fluciclovine uptake by BCH and MeAIB can be demonstrated in vivo similar to previous in vitro modeling.",
keywords = "Amino acid transport, Axumin, Fluciclovine, PC3, Prostate cancer",
author = "Tade, {F. I.} and Wiles, {W. G.} and G. Lu and B. Bilir and O. Akin-Akintayo and Lee, {J. S.} and D. Patil and W. Yu and {Ormenisan Gherasim}, C. and B. Fei and Moreno, {C. S.} and Osunkoya, {A. O.} and Teoh, {E. J.} and S. Oka and H. Okudaira and Goodman, {M. M.} and Schuster, {D. M.}",
note = "Funding Information: Research reported in this publication was supported in part by the Cancer Animal Models Shared Resource, a core supported by the Winship Cancer Institute of Emory University and Cancer Center Support Grant P30 CA138292. Emory University licensed and approved the 18F-fluciclovine patent technology in accordance with the Emory Conflict of Interest Committee policies. M. M. Goodman and Emory University are eligible to receive royalties derived from the sale of 18F-fluciclovine. H. Okudaira and S. Oka are employees of Nihon Medi-Physics Co., Ltd. (NMP) and collaborate with M. M. Goodman and D. M. Schuster on preclinical and clinical studies involving 18F-fluciclovine. F. I. Tade, O. Akin-Akintayo, and D. M. Schuster receive funding/resources from Blue Earth Diagnostics Ltd. and Nihon Medi-Physics Co., Ltd. through the Emory University Office of Sponsored Projects for research outside that reported in this manuscript. All other co-authors declared no conflicts of interest. Funding Information: Acknowledgements Research reported in this publication was supported in part by the Cancer Animal Models Shared Resource, a core supported by the Winship Cancer Institute of Emory University and Cancer Center Support Grant P30 CA138292. Publisher Copyright: {\textcopyright} 2018, Springer-Verlag GmbH Austria, part of Springer Nature.",
year = "2018",
month = sep,
day = "1",
doi = "10.1007/s00726-018-2600-0",
language = "English (US)",
volume = "50",
pages = "1301--1305",
journal = "Amino Acids",
issn = "0939-4451",
publisher = "Springer Wien",
number = "9",
}