TY - JOUR
T1 - Seizures in glioma patients
T2 - An overview of incidence, etiology, and therapies
AU - Samudra, Niyatee
AU - Zacharias, T.
AU - Plitt, A.
AU - Lega, Bradley
AU - Pan, Edward
N1 - Publisher Copyright:
© 2019
PY - 2019/9/15
Y1 - 2019/9/15
N2 - Gliomas are fatal brain tumors, and even low-grade gliomas (LGGs) have an average survival of less than a decade. Seizures are a common presentation of gliomas, particularly LGGs, and substantially impact quality of life. Glioma-related seizures differ from other focal epilepsies in their pathogenesis and in the likelihood of refractory epilepsy. We review factors that predict seizure activity and response to treatment, optimal pharmacologic and surgical management of glioma-related epilepsy, and the benefit of using newer anti-seizure medications in patients with gliomas. As surgery is so often beneficial with seizure reduction, we discuss oncologic and epilepsy surgery perspectives. Treatment of gliomas has the potential to ameliorate seizures and increase rates of seizure freedom. Prospective, well-powered studies are needed to provide more definitive answers for practitioners taking care of glioma patients with seizures.
AB - Gliomas are fatal brain tumors, and even low-grade gliomas (LGGs) have an average survival of less than a decade. Seizures are a common presentation of gliomas, particularly LGGs, and substantially impact quality of life. Glioma-related seizures differ from other focal epilepsies in their pathogenesis and in the likelihood of refractory epilepsy. We review factors that predict seizure activity and response to treatment, optimal pharmacologic and surgical management of glioma-related epilepsy, and the benefit of using newer anti-seizure medications in patients with gliomas. As surgery is so often beneficial with seizure reduction, we discuss oncologic and epilepsy surgery perspectives. Treatment of gliomas has the potential to ameliorate seizures and increase rates of seizure freedom. Prospective, well-powered studies are needed to provide more definitive answers for practitioners taking care of glioma patients with seizures.
KW - cancer
KW - epilepsy
KW - glioma
KW - review
KW - seizure
UR - http://www.scopus.com/inward/record.url?scp=85069739540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069739540&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2019.07.026
DO - 10.1016/j.jns.2019.07.026
M3 - Review article
C2 - 31352293
AN - SCOPUS:85069739540
SN - 0022-510X
VL - 404
SP - 80
EP - 85
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -