Segmental and dynamic intensity-modulated radiotherapy delivery techniques for micro-multileaf collimator

Nzhde Agazaryan, Timothy D. Solberg

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A leaf sequencing algorithm has been implemented to deliver segmental and dynamic multileaf collimated intensity-modulated radiotherapy (SMLC-IMRT and DMLC-IMRT, respectively) using a linear accelerator equipped with a micro-multileaf collimator (mMLC). The implementation extends a previously published algorithm for the SMLC-IMRT to include the dynamic MLC-IMRT method and several dosimetric considerations. The algorithm has been extended to account for the transmitted radiation and minimize the leakage between opposing and neighboring leaves. The underdosage problem associated with the tongue-and-groove design of the MLC is significantly reduced by synchronizing the MLC leaf movements. The workings of the leaf sequencing parameters have been investigated and the results of the planar dosimetric investigations show that the sequencing parameters affect the measured dose distributions as intended. Investigations of clinical cases suggest that SMLC and DMLC delivery methods produce comparable results with leaf sequences obtained by root-mean-square (RMS) errors specification of 1.5% and lower, approximately corresponding to 20 or more segments. For SMLC-IMRT, there is little to be gained by using an RMS error specification smaller than 2%, approximately corresponding to 15 segments; however, more segments directly translate to longer treatment time and more strain on the MLC. The implemented leaf synchronization method does not increase the required monitor units while it reduces the measured TG underdoses from a maximum of 12% to a maximum of 3% observed with single field measurements of representative clinical cases studied.

Original languageEnglish (US)
Pages (from-to)1758-1767
Number of pages10
JournalMedical physics
Issue number7
StatePublished - Jul 1 2003


  • DMLC
  • IMRT
  • Leaf sequencing
  • Radiotherapy
  • SMLC

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


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