TY - JOUR
T1 - Secondary myelodysplastic syndrome complicating therapy for osteogenic sarcoma
AU - Pappo, A.
AU - Schneider, N. R.
AU - Sanders, J. M.
AU - Buchanan, G. R.
PY - 1991/9/15
Y1 - 1991/9/15
N2 - A 12‐year‐old girl with nonmetastatic osteogenic sarcoma received treatment with doxorubicin, methotrexate, cisplatin, cyclophosphamide, bleomycin, and dactinomycin. She developed unexplained persistent pancytopenia after completion of chemotherapy. Twenty‐three months after the initial diagnosis of osteosarcoma an evaluation revealed a bone marrow pattern consistent with the diagnosis of refractory anemia with excess blasts, and karyotype analysis showed characteristic findings of therapy‐related myelodysplasia (loss of chromosomes 5 and 7, as well as 12p and 17p deletions). Bone marrow transplantation from an human leukocyte antigen (HLA)‐compatible sibling donor was performed 26 months after the diagnosis of the primary malignancy. Although it is unproven that the alkylating agents administered to this patient were responsible for the myelodysplastic syndrome, careful follow‐up of osteosarcoma patients who receive alkylating agents is warranted.
AB - A 12‐year‐old girl with nonmetastatic osteogenic sarcoma received treatment with doxorubicin, methotrexate, cisplatin, cyclophosphamide, bleomycin, and dactinomycin. She developed unexplained persistent pancytopenia after completion of chemotherapy. Twenty‐three months after the initial diagnosis of osteosarcoma an evaluation revealed a bone marrow pattern consistent with the diagnosis of refractory anemia with excess blasts, and karyotype analysis showed characteristic findings of therapy‐related myelodysplasia (loss of chromosomes 5 and 7, as well as 12p and 17p deletions). Bone marrow transplantation from an human leukocyte antigen (HLA)‐compatible sibling donor was performed 26 months after the diagnosis of the primary malignancy. Although it is unproven that the alkylating agents administered to this patient were responsible for the myelodysplastic syndrome, careful follow‐up of osteosarcoma patients who receive alkylating agents is warranted.
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U2 - 10.1002/1097-0142(19910915)68:6<1373::AID-CNCR2820680631>3.0.CO;2-S
DO - 10.1002/1097-0142(19910915)68:6<1373::AID-CNCR2820680631>3.0.CO;2-S
M3 - Article
C2 - 1714791
AN - SCOPUS:0026006077
SN - 0008-543X
VL - 68
SP - 1373
EP - 1375
JO - Cancer
JF - Cancer
IS - 6
ER -