Abstract
Objective: To determine the risks and benefits of secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer. Methods: Data were obtained retrospectively for all women with recurrent platinum-sensitive epithelial ovarian cancer who underwent a second debulking operation between 1998 and 2008 at the University of Texas Southwestern Medical Center. Survival analysis and comparisons were performed using the Kaplan-Meier method, log-rank test, and Cox multivariate proportional hazards model. Results: Optimal secondary cytoreductive surgery (< 5 mm of residual disease) was achieved in 32 of 40 patients (80%). Nine women (23%) developed major complications. Two variables, residual disease of less than 5 mm vs 5 mm or greater (median 63 months vs 11 months; P = 0.003); and less than 5 vs 5 or more sites of disease relapse (median 63 months vs 22 months; P = 0.009), were independently associated with survival and retained prognostic significance on multivariate analysis. Conclusions: Optimal secondary cytoreductive surgery was associated with a survival advantage and acceptable risks.
Original language | English (US) |
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Pages (from-to) | 123-127 |
Number of pages | 5 |
Journal | International Journal of Gynecology and Obstetrics |
Volume | 108 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2010 |
Keywords
- Recurrent ovarian cancer
- Secondary cytoreductive surgery
ASJC Scopus subject areas
- Obstetrics and Gynecology