Searching Chromatin for Stem Cell Identity

Michael Buszczak; Allan C. Spradling

doi:10.1016/j.cell.2006.04.004

Searching Chromatin for Stem Cell Identity

Michael Buszczak, Allan C. Spradling

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Stem cells encapsulate the fundamental problem of metazoan biology in miniature: How do cells establish and maintain their fates? Increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how these configurations are stabilized by Polycomb group proteins will advance our understanding of embryonic development, tissue homeostasis, regeneration, aging, and oncogenesis.

Original language	English (US)
Pages (from-to)	233-236
Number of pages	4
Journal	Cell
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2006.04.004
State	Published - Apr 21 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2006.04.004

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title = "Searching Chromatin for Stem Cell Identity",

abstract = "Stem cells encapsulate the fundamental problem of metazoan biology in miniature: How do cells establish and maintain their fates? Increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how these configurations are stabilized by Polycomb group proteins will advance our understanding of embryonic development, tissue homeostasis, regeneration, aging, and oncogenesis.",

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AU - Spradling, Allan C.

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AB - Stem cells encapsulate the fundamental problem of metazoan biology in miniature: How do cells establish and maintain their fates? Increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how these configurations are stabilized by Polycomb group proteins will advance our understanding of embryonic development, tissue homeostasis, regeneration, aging, and oncogenesis.

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M3 - Short survey

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JO - Cell

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Searching Chromatin for Stem Cell Identity

Abstract

ASJC Scopus subject areas

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