Screening initiation with FIT or colonoscopy: Post-hoc analysis of a pragmatic, randomized trial

Caitlin Claffey Murphy, Chul Ahn, Sandi Pruitt, Amy E. Hughes, Ethan A Halm, Samir Gupta, Noel O. Santini, Katharine McCallister, Joanne M. Sanders, Amit Singal, Celette S Skinner

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Screening with FIT or colonoscopy can reduce CRC mortality. In our pragmatic, randomized trial of screening outreach over three years, patients annually received mailed FITs or colonoscopy invitations. We examined screening initiation after each mailing and crossover from the invited to other modality. Eligible patients (50–64 years, ≥1 primary-care visit before randomization, and no history of CRC) received mailed FIT kits (n = 2400) or colonoscopy invitations (n = 2400) from March 2013 through July 2016. Among those invited for colonoscopy, we used multinomial logistic regression to identify factors associated with screening initiation with colonoscopy vs. FIT vs. no screening after the first mailing. Most patients were female (61.8%) and Hispanic (48.9%) or non-Hispanic black (24.0%). Among those invited for FIT, 56.6% (n = 1359) initiated with FIT, whereas 3.3% (n = 78) crossed over to colonoscopy; 151 (15.7%) and 61 (7.7%) initiated with FIT after second and third mailings. Among those invited for colonoscopy, 25.5% (n = 613) initiated with colonoscopy whereas 18.8% (n = 452) crossed over to FIT; 112 (8.4%) and 48 (4.2%) initiated with colonoscopy after second and third mailings. Three or more primary-care visits prior to randomization were associated with initiating with colonoscopy (OR 1.49, 95% CI 1.17–1.91) and crossing over to FIT (OR 1.63, 95% CI 1.19–2.23). Although nearly half of patients initiated screening after the first mailing, few non-responders in either outreach group initiated after a second or third mailing. More patients invited to colonoscopy crossed over to FIT than those assigned to FIT crossed over to colonoscopy.

Original languageEnglish (US)
Pages (from-to)332-335
Number of pages4
JournalPreventive Medicine
StatePublished - Jan 2019


  • Colorectal neoplasms
  • Health promotion
  • Mass screening
  • Pragmatic clinical trial
  • Safety-net providers

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Screening initiation with FIT or colonoscopy: Post-hoc analysis of a pragmatic, randomized trial'. Together they form a unique fingerprint.

Cite this