Screening for microalbuminuria: A comparison of single sample methods of collection and techniques of albumin analysis

Steve J. Schwab, Fredrick L. Dunn, Mark N. Feinglos

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


OBJECTIVE - To evaluate single-sample urine collections to determine their ability to screen patients for the presence of microalbuminuria. Microalbuminuria in patients with type I diabetes predicts the development of diabetic renal disease. RESEARCH DESIGN AND METHODS - Cross-sectional analysis of single-sample urine collection techniques (first morning void, random upright void) and methods of albumin analysis (RIA, reagent tablet) were compared with conventional 24-h urine collections (RIA). The study included 94 patients (45 males, 49 females; mean serum creatinine 88 μM) with type I diabetes, selected from a screened population of 301 patients from the University Hospital Subspecialty Clinics. RESULTS - A 24-hour urine collection RIA analysis for albumin revealed 36 normal patients (<30 mg), 27 with microalbuminuria (30-300 mg), and 31 with albuminuria (>300 mg). Random upright urine samples were more sensitive (RIA 89%, tablets 78%) for the detection of microalbuminuria than first morning void specimens (RIA 70%, tablets 60%). Specificity was >80% with both random and first morning voids. CONCLUSIONS - Screening for microalbuminuria can be performed in the clinic by random upright single-sample urine collections. When reagent tablets are used, these results are available immediately. Patients who screen positive should be confirmed by 24-h or other timed urine collections.

Original languageEnglish (US)
Pages (from-to)1581-1584
Number of pages4
JournalDiabetes care
Issue number11
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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