SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

Camille Tlemsani; Lorinc Pongor; Fathi Elloumi; Luc Girard; Kenneth E. Huffman; Nitin Roper; Sudhir Varma; Augustin Luna; Vinodh N. Rajapakse; Robin Sebastian; Kurt W. Kohn; Julia Krushkal; Mirit I. Aladjem; Beverly A. Teicher; Paul S. Meltzer; William C. Reinhold; John D. Minna; Anish Thomas; Yves Pommier

doi:10.1016/j.celrep.2020.108296

SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

Camille Tlemsani, Lorinc Pongor, Fathi Elloumi, Luc Girard, Kenneth E. Huffman, Nitin Roper, Sudhir Varma, Augustin Luna, Vinodh N. Rajapakse, Robin Sebastian, Kurt W. Kohn, Julia Krushkal, Mirit I. Aladjem, Beverly A. Teicher, Paul S. Meltzer, William C. Reinhold, John D. Minna, Anish Thomas, Yves Pommier

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Abstract

Tlemsani et al. provide a unique resource, SCLC-CellMiner, integrating drug sensitivity and multi-omics data from 118 small cell lung cancer (SCLC) cell lines. They demonstrate that SCLCs have differential transcriptional networks driven by lineage-specific transcription factors (NEUROD1, ASCL1, POU2F3, and YAP1). Furthermore, YAP1-driven SCLCs have distinct drug sensitivity profiles.

Original language	English (US)
Article number	108296
Journal	Cell Reports
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.108296
State	Published - Oct 20 2020

Keywords

PARP
SLFN11
STING
Schlafen
genomics
immune checkpoints
mutations
native immune response
neuroendocrine tumors
replication

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2020.108296

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Tlemsani, C., Pongor, L., Elloumi, F., Girard, L., Huffman, K. E., Roper, N., Varma, S., Luna, A., Rajapakse, V. N., Sebastian, R., Kohn, K. W., Krushkal, J., Aladjem, M. I., Teicher, B. A., Meltzer, P. S., Reinhold, W. C., Minna, J. D., Thomas, A., & Pommier, Y. (2020). SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures. Cell Reports, 33(3), Article 108296. https://doi.org/10.1016/j.celrep.2020.108296

Tlemsani, C, Pongor, L, Elloumi, F, Girard, L, Huffman, KE, Roper, N, Varma, S, Luna, A, Rajapakse, VN, Sebastian, R, Kohn, KW, Krushkal, J, Aladjem, MI, Teicher, BA, Meltzer, PS, Reinhold, WC, Minna, JD, Thomas, A & Pommier, Y 2020, 'SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures', Cell Reports, vol. 33, no. 3, 108296. https://doi.org/10.1016/j.celrep.2020.108296

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abstract = "Tlemsani et al. provide a unique resource, SCLC-CellMiner, integrating drug sensitivity and multi-omics data from 118 small cell lung cancer (SCLC) cell lines. They demonstrate that SCLCs have differential transcriptional networks driven by lineage-specific transcription factors (NEUROD1, ASCL1, POU2F3, and YAP1). Furthermore, YAP1-driven SCLCs have distinct drug sensitivity profiles.",

keywords = "PARP, SLFN11, STING, Schlafen, genomics, immune checkpoints, mutations, native immune response, neuroendocrine tumors, replication",

author = "Camille Tlemsani and Lorinc Pongor and Fathi Elloumi and Luc Girard and Huffman, {Kenneth E.} and Nitin Roper and Sudhir Varma and Augustin Luna and Rajapakse, {Vinodh N.} and Robin Sebastian and Kohn, {Kurt W.} and Julia Krushkal and Aladjem, {Mirit I.} and Teicher, {Beverly A.} and Meltzer, {Paul S.} and Reinhold, {William C.} and Minna, {John D.} and Anish Thomas and Yves Pommier",

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AU - Elloumi, Fathi

AU - Girard, Luc

AU - Huffman, Kenneth E.

AU - Roper, Nitin

AU - Varma, Sudhir

AU - Luna, Augustin

AU - Rajapakse, Vinodh N.

AU - Sebastian, Robin

AU - Kohn, Kurt W.

AU - Krushkal, Julia

AU - Aladjem, Mirit I.

AU - Teicher, Beverly A.

AU - Meltzer, Paul S.

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AU - Minna, John D.

AU - Thomas, Anish

AU - Pommier, Yves

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KW - mutations

KW - native immune response

KW - neuroendocrine tumors

KW - replication

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SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

Abstract

Keywords

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