@article{d779e5e43c20468fa94e5faaaa252e23,
title = "Satiety behavior is regulated by ASI/ASH reciprocal antagonism",
abstract = "Appropriate decision-making is essential for ensuring survival; one such decision is whether to eat. Overall metabolic state and the safety of food are the two factors we examined using C. elegans to ask whether the metabolic state regulates neuronal activities and corresponding feeding behavior. We monitored the activity of sensory neurons that are activated by nutritious (or appetitive) stimuli (ASI) and aversive stimuli (ASH) in starved vs. well-fed worms during stimuli presentation. Starvation reduces ASH activity to aversive stimuli while increasing ASI activity to nutritious stimuli, showing the responsiveness of each neuron is modulated by overall metabolic state. When we monitored satiety quiescence behavior that reflects the overall metabolic state, ablation of ASI and ASH produce the opposite behavior, showing the two neurons interact to control the decision to eat or not. This circuit provides a simple approach to how neurons handle sensory conflict and reach a decision that is translated to behavior.",
author = "Davis, {Kristen C.} and Choi, {Young In} and Jeongho Kim and You, {Young Jai}",
note = "Funding Information: We thank Drs. Bargmann, Schaeffer, Hirotsu, Iino, Ishihara, and the Caenorhabditis Genetics Center for strains (NIH grant P40 OD010440). We thank Drs. Gallagher, Avery, Davies, and Raizen for invaluable discussion. We thank Lindsey Lopes for providing feedback on the manuscript. We thank Dr. Zimmer for initially providing the olfactory chips for this project. This work was supported by NIH grant 5R01DK083593 (YY, KD), Inha University (JK), Medical School of Virginia Commonwealth University (YY, KD) and Nagoya Neuroscience Institute (YY). Funding Information: We thank Drs. Bargmann, Schaefer, Hirotsu, Iino, Ishihara, and the Caenorhabditis Genetics Center for strains (NIH grant P40 OD010440). We thank Drs. Gallagher, Avery, Davies, and Raizen for invaluable discussion. We thank Lindsey Lopes for providing feedback on the manuscript. We thank Dr. Zimmer for initially providing the olfactory chips for this project. Tis work was supported by NIH grant 5R01DK083593 (YY, KD), Inha University (JK), Medical School of Virginia Commonwealth University (YY, KD) and Nagoya Neuroscience Institute (YY). Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-24943-6",
language = "English (US)",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}