Abstract
Immunocompromised patients can experience prolonged SARS-CoV-2 infections in the setting of a lack of protectivity immunity despite vaccination. As circulating SARS-CoV-2 strains become more heterogeneous, concomitant infection with multiple SARS-CoV-2 variants has become an increasing concern. Immunocompromised patient populations represent potential reservoirs for the emergence of novel SARS-CoV-2 variants through mutagenic change or coinfection followed by recombinatory events. Identification of SARS-CoV-2 coinfections is challenging using traditional next generation sequencing pipelines; however, targeted genotyping approaches can facilitate detection. Here we describe five COVID-19 cases caused by coinfection with different SARS-CoV-2 variants (Delta/Omicron BA.1 and Omicron BA.1/BA.2) as identified by multiplex fragment analysis.
Original language | English (US) |
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Article number | 942713 |
Journal | Frontiers in Genetics |
Volume | 13 |
DOIs | |
State | Published - Sep 26 2022 |
Keywords
- COVID-19
- SARS-CoV-2
- co-infection
- fragment analysis
- multiplex (RT)-PCR
- omicron
- variant
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Genetics(clinical)