S49 lymphoma wild type and variant clones contain normal calcium dependent regulator

W. H. Burgess; A. C. Howlett; R. H. Kretsinger; A. G. Gilman

S49 lymphoma wild type and variant clones contain normal calcium dependent regulator

W. H. Burgess, A. C. Howlett, R. H. Kretsinger, A. G. Gilman

Pharmacology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Calcium dependent regulator is present in wild-type S49 lymphoma cells, in the variant that is deficient in adenylate cyclase activity (AC^-), and in the uncoupled variant (UNC). The electrophoretic mobility and the ability to stimulate cyclic nucleotide phosphodiesterase of the calcium dependent regulator from each of these 3 clones are indistinguishable from those of the modulator protein isolated from bovine brain. Calcium dependent regulator does not appear to be involved in the defect responsible for the UNC or AC^- variants.

Original language	English (US)
Pages (from-to)	175-181
Number of pages	7
Journal	Journal of Cyclic Nucleotide Research
Volume	4
Issue number	3
State	Published - Dec 1 1978

ASJC Scopus subject areas

Medicine(all)

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title = "S49 lymphoma wild type and variant clones contain normal calcium dependent regulator",

abstract = "Calcium dependent regulator is present in wild-type S49 lymphoma cells, in the variant that is deficient in adenylate cyclase activity (AC-), and in the uncoupled variant (UNC). The electrophoretic mobility and the ability to stimulate cyclic nucleotide phosphodiesterase of the calcium dependent regulator from each of these 3 clones are indistinguishable from those of the modulator protein isolated from bovine brain. Calcium dependent regulator does not appear to be involved in the defect responsible for the UNC or AC- variants.",

author = "Burgess, {W. H.} and Howlett, {A. C.} and Kretsinger, {R. H.} and Gilman, {A. G.}",

year = "1978",

month = dec,

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language = "English (US)",

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journal = "Journal of Receptor and Signal Transduction Research",

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T1 - S49 lymphoma wild type and variant clones contain normal calcium dependent regulator

AU - Burgess, W. H.

AU - Howlett, A. C.

AU - Kretsinger, R. H.

AU - Gilman, A. G.

PY - 1978/12/1

Y1 - 1978/12/1

N2 - Calcium dependent regulator is present in wild-type S49 lymphoma cells, in the variant that is deficient in adenylate cyclase activity (AC-), and in the uncoupled variant (UNC). The electrophoretic mobility and the ability to stimulate cyclic nucleotide phosphodiesterase of the calcium dependent regulator from each of these 3 clones are indistinguishable from those of the modulator protein isolated from bovine brain. Calcium dependent regulator does not appear to be involved in the defect responsible for the UNC or AC- variants.

AB - Calcium dependent regulator is present in wild-type S49 lymphoma cells, in the variant that is deficient in adenylate cyclase activity (AC-), and in the uncoupled variant (UNC). The electrophoretic mobility and the ability to stimulate cyclic nucleotide phosphodiesterase of the calcium dependent regulator from each of these 3 clones are indistinguishable from those of the modulator protein isolated from bovine brain. Calcium dependent regulator does not appear to be involved in the defect responsible for the UNC or AC- variants.

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AN - SCOPUS:0018190965

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JO - Journal of Receptor and Signal Transduction Research

JF - Journal of Receptor and Signal Transduction Research

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ER -

S49 lymphoma wild type and variant clones contain normal calcium dependent regulator

Abstract

ASJC Scopus subject areas

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