Abstract
Restless legs syndrome (RLS) is a chronic neurological disorder associated with sleep disturbance. Ropinirole, a non-ergot dopamine agonist, has been widely studied for the treatment of moderate-to-severe primary RLS in a comprehensive clinical development program. In these studies, ropinirole was effective in significantly improving the symptoms of RLS, compared with placebo, in patients with moderate-to-severe primary RLS. These improvements are supported by data from individual studies, as well as by pooled analyses. Significant improvements in RLS symptoms were observed within 2 nights of treatment. Ropinirole also produced significant benefits on objective measures of RLS motor symptoms, such as periodic leg movements; and on subjective measures of sleep, ropinirole was generally well tolerated. A newly developed extended-release formulation of ropinirole may benefit patients who warrant an extended duration of therapy.
Original language | English (US) |
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Pages (from-to) | 655-664 |
Number of pages | 10 |
Journal | Expert Opinion on Drug Metabolism and Toxicology |
Volume | 4 |
Issue number | 5 |
DOIs | |
State | Published - May 2008 |
Keywords
- Dopamine agonist
- Restless legs syndrome
- Ropinirole
ASJC Scopus subject areas
- Toxicology
- Pharmacology