Abstract
Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut. (Inflamm Bowel Dis 2010)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1963-1968 |
| Number of pages | 6 |
| Journal | Inflammatory bowel diseases |
| Volume | 16 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2010 |
Keywords
- cancer risk
- carcinogenesis
- chronic inflammation
- inflammatory bowel disease
- transforming growth factor-β
ASJC Scopus subject areas
- Immunology and Allergy
- Gastroenterology