TY - JOUR
T1 - Role of serotonin type-1A/B (hydroxytryptamine) receptors in depression revisited
AU - Kanade, Prateek
AU - Gupta, Deepali
AU - Radhakrishnan, Mahesh
AU - Prabhakar, Visakh
PY - 2013
Y1 - 2013
N2 - Depression is among the common psychiatric disorders, therefore the common pathways and pathogenesis associated with depression is required to be studied. In few years, role of 5-hydroxytryptamine-1A/B (5-HT 1A/B ) receptors in depressive disorders have been revealed. Both preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT 1A/B receptors have significant modulatory effects in depression. However, the collective details regarding the involvement of 5-HT 1A/B receptors and the molecular pathways associated in depression is lacking. Thus, the present review evidence the link between 5-HT 1A/B receptors in the brain and depression, the possible pathways involved and their alterations in depression. Further, it reviews the preclinical evidences of 5-HT 1A/B receptor modulators as antidepressant agents and their effectiveness. The current review also details the clinical relevance of 5-HT 1A/B receptors etiopathogenesis of major depression in humans.
AB - Depression is among the common psychiatric disorders, therefore the common pathways and pathogenesis associated with depression is required to be studied. In few years, role of 5-hydroxytryptamine-1A/B (5-HT 1A/B ) receptors in depressive disorders have been revealed. Both preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT 1A/B receptors have significant modulatory effects in depression. However, the collective details regarding the involvement of 5-HT 1A/B receptors and the molecular pathways associated in depression is lacking. Thus, the present review evidence the link between 5-HT 1A/B receptors in the brain and depression, the possible pathways involved and their alterations in depression. Further, it reviews the preclinical evidences of 5-HT 1A/B receptor modulators as antidepressant agents and their effectiveness. The current review also details the clinical relevance of 5-HT 1A/B receptors etiopathogenesis of major depression in humans.
KW - Depression
KW - Molecular signaling
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U2 - 10.4103/0975-8453.135831
DO - 10.4103/0975-8453.135831
M3 - Review article
AN - SCOPUS:84906729389
SN - 0975-8453
VL - 4
SP - 7
EP - 13
JO - Systematic Reviews in Pharmacy
JF - Systematic Reviews in Pharmacy
IS - 1
ER -