Role of serotonin type-1A/B (hydroxytryptamine) receptors in depression revisited

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Depression is among the common psychiatric disorders, therefore the common pathways and pathogenesis associated with depression is required to be studied. In few years, role of 5-hydroxytryptamine-1A/B (5-HT 1A/B ) receptors in depressive disorders have been revealed. Both preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT 1A/B receptors have significant modulatory effects in depression. However, the collective details regarding the involvement of 5-HT 1A/B receptors and the molecular pathways associated in depression is lacking. Thus, the present review evidence the link between 5-HT 1A/B receptors in the brain and depression, the possible pathways involved and their alterations in depression. Further, it reviews the preclinical evidences of 5-HT 1A/B receptor modulators as antidepressant agents and their effectiveness. The current review also details the clinical relevance of 5-HT 1A/B receptors etiopathogenesis of major depression in humans.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalSystematic Reviews in Pharmacy
Issue number1
StatePublished - 2013
Externally publishedYes


  • Depression
  • Molecular signaling

ASJC Scopus subject areas

  • Pharmaceutical Science


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