Role of Sentinel Lymph Node Biopsy in Microinvasive Breast Cancer

Betty Fan, Jaime A. Pardo, Stephanie Serres, Amulya C. Alapati, Joanne Szewczyk, Alessandra Mele, Ted A. James

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Microinvasive ductal carcinoma (DCISM), defined as DCIS with a focus of invasive carcinoma ≤ 1 mm, can be managed similarly to pure DCIS; however, management of the axilla in DCISM has been a subject of debate. Reports in the literature differ on the utility and necessity of sentinel lymph node biopsy (SLNB) for DCISM. The aim of the present study was to identify risk factors for nodal disease in patients with DCISM, which can help develop a selective approach to SLNB in this patient population. Methods: The National Cancer Database was used to select patients with DCISM (pT1mi), diagnosed from 2012 to 2015, who underwent SLNB. Multivariable regression analysis was performed to determine associations between sentinel lymph node metastasis and relevant clinical variables. Results: Our cohort comprised of 2609 patients with pT1mi who underwent SLNB. Of these, 76 (2.9%) were found to have sentinel lymph node metastases on final pathology. Low/intermediate grade tumors were associated with decreased SLN metastasis (OR 0.50, CI 0.28–0.92). Age and receptor status of the tumor did not have a clear association in predicting SLN metastases. Conclusions: The rate of sentinel node metastases in DCISM is low at only 2.9% in this national study. Tumor grade was identified as influencing the risk of SLN metastases. This information can factor into shared decision-making for SLNB in patients with DCISM.

Original languageEnglish (US)
Pages (from-to)4468-4473
Number of pages6
JournalAnnals of Surgical Oncology
Issue number11
StatePublished - Oct 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oncology


Dive into the research topics of 'Role of Sentinel Lymph Node Biopsy in Microinvasive Breast Cancer'. Together they form a unique fingerprint.

Cite this