TY - JOUR
T1 - Role of calcineurin in striated muscle
T2 - Development, adaptation, and disease
AU - Bassel-Duby, Rhonda
AU - Olson, Eric N.
N1 - Funding Information:
We thank Alisha Tizenor for assistance with the manuscript. The authors are supported by grants from National Institutes of Health, the Donald W. Reynolds Foundation, and the William G. McGowan Charitable Fund (to E.N.O.).
PY - 2003/11/28
Y1 - 2003/11/28
N2 - Striated muscles, cardiac and skeletal muscles, use calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium activate calcineurin, a serine/threonine phosphatase, resulting in expression of a set of genes involved in remodeling striated muscle. Activation of calcineurin in hearts produces cardiac hypertrophy, and in skeletal muscle promotes cell differentiation and transforms fiber type specificity. In this review we discuss the effects of calcineurin activity on development, adaptation, and disease of striated muscle.
AB - Striated muscles, cardiac and skeletal muscles, use calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium activate calcineurin, a serine/threonine phosphatase, resulting in expression of a set of genes involved in remodeling striated muscle. Activation of calcineurin in hearts produces cardiac hypertrophy, and in skeletal muscle promotes cell differentiation and transforms fiber type specificity. In this review we discuss the effects of calcineurin activity on development, adaptation, and disease of striated muscle.
UR - http://www.scopus.com/inward/record.url?scp=0242606147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242606147&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2003.09.020
DO - 10.1016/j.bbrc.2003.09.020
M3 - Article
C2 - 14623299
AN - SCOPUS:0242606147
SN - 0006-291X
VL - 311
SP - 1133
EP - 1141
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -