@inbook{ea09fe1c56b94a85a7fd3a014c2be0ec,
title = "RNA-mediated gene activation: Identifying a candidate RNA for preclinical development",
abstract = "The ability to activate gene expression would provide new opportunities for drug development for diseases caused by inadequate or nonexistent expression of a therapeutic protein. Duplex RNAs that target gene promoters are one strategy for enhancing the expression of target genes. This chapter summarizes our understanding of mechanism behind gene activation by small RNAs that bind noncoding transcripts at gene promoters. We describe a path for choosing candidate genes for therapeutic development.",
keywords = "Duplex RNA, Gene activation, Noncoding RNA, Nucleic acid therapeutics, RNA",
author = "Corey, {David R.}",
note = "Publisher Copyright: {\textcopyright} 2017, Springer Nature Singapore Pte Ltd.",
year = "2017",
doi = "10.1007/978-981-10-4310-9_11",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "161--171",
booktitle = "Advances in Experimental Medicine and Biology",
}