TY - JOUR
T1 - Risperidone in first-episode psychosis
T2 - A longitudinal, exploratory voxel-based morphometric study
AU - Girgis, Ragy R.
AU - Diwadkar, Vaibhav A.
AU - Nutche, Jeffrey J.
AU - Sweeney, John A.
AU - Keshavan, Matcheri S.
AU - Hardan, Antonio Y.
N1 - Funding Information:
This work was supported in part by NIMH grants MH45203, 01180 and 45156 (MSK) and GCRC grant M01 RR00056. We gratefully acknowledge Cameron S. Carter, MD, Gretchen L. Haas, PhD, Debra M. Montrose, PhD, Elizabeth Radomsky, PhD, Nina R. Schooler, PhD, Nancy M. McLaughlin, RN, BSN, and Kevin Eklund for their help with subject recruitment and clinical assessments. We also gratefully acknowledge the effort and commitment of the patients and their families.
PY - 2006/2/15
Y1 - 2006/2/15
N2 - Previous studies have provided evidence supporting a neuroplastic effect of atypical antipsychotics. The present investigation explores the short-term effects of risperidone on brain parenchyma by performing voxel-based morphometry on baseline and 6-week follow-up MRI scans obtained from 15 neuroleptic-naïve individuals with first-episode psychosis treated with risperidone and 15 healthy controls. The risperidone-treated subjects demonstrated changes in grey matter and white matter in several brain regions, including superior temporal gyrus. No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis.
AB - Previous studies have provided evidence supporting a neuroplastic effect of atypical antipsychotics. The present investigation explores the short-term effects of risperidone on brain parenchyma by performing voxel-based morphometry on baseline and 6-week follow-up MRI scans obtained from 15 neuroleptic-naïve individuals with first-episode psychosis treated with risperidone and 15 healthy controls. The risperidone-treated subjects demonstrated changes in grey matter and white matter in several brain regions, including superior temporal gyrus. No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis.
KW - Atypical antipsychotics
KW - First-episode psychosis
KW - Neuroplasticity
KW - Risperidone
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=32044449826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32044449826&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2005.10.019
DO - 10.1016/j.schres.2005.10.019
M3 - Article
C2 - 16413757
AN - SCOPUS:32044449826
SN - 0920-9964
VL - 82
SP - 89
EP - 94
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -