Risk factors for mild cognitive impairment among Mexican Americans

Sid E. O'Bryant, Leigh Johnson, Joan Reisch, Melissa Edwards, James Hall, Robert Barber, Michael D. Devous, Donald Royall, Meharvan Singh

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Background: Although a great deal of literature has focused on risk factors for mild cognitive impairment (MCI), little published work examines risk for MCI among Mexican Americans. Methods: Data from 1628 participants (non-Hispanic n = 1002; Mexican American n = 626) were analyzed from two ongoing studies of cognitive aging and Alzheimer's disease, Project FRONTIER (Facing Rural Obstacles to health Now Through Intervention, Education & Research) and TARCC (Texas Alzheimer's Research & Care Consortium). Results: When looking at the full cohorts (non-Hispanic and Mexican American), age, education, Apolipoprotein E (APOE) ε4 status and gender were consistently related to MCI diagnosis across the two cohorts. However, when split by ethnicity, advancing age was the only significant risk factor for MCI among Mexican Americans across both cohorts. Conclusions: The current data suggest that many of the previously established risk factors for MCI among non-Hispanic cohorts may not be predictive of MCI among Mexican Americans and point to the need for additional work aimed at understanding factors related to cognitive aging among this underserved segment of the population.

Original languageEnglish (US)
Pages (from-to)622-631.e1
JournalAlzheimer's and Dementia
Issue number6
StatePublished - Nov 2013


  • Alzheimer's disease
  • Cognition
  • Cross-cultural
  • Ethnicity
  • Mexican American
  • Mild cognitive impairment
  • Risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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