Risk factors for locoregional relapse after radical nephrectomy

Sameer Jhavar, Gregory Swanson, Jessica Pruszynski

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Aim: To identify risk factors for locoregional relapse after radical nephrectomy for renal cell carcinoma. Methods: We retrospectively reviewed the charts of 259 patients who underwent radical nephrectomy for sporadic clinically localized unilateral renal cell carcinoma between 1998 and 2012. Relapse patterns (locoregional and/or distant) were identified. Relapse-free survival was calculated using Kaplan-Meier method. Factors associated with decreased relapse-free survival were identified using univariate and multivariate Cox proportional hazards regression model analysis. Locoregional relapse estimates were calculated for individual factors and combination of factors. Results: At a median follow-up of 68 months (interquartile range: 75 months), 24% patients relapsed. Of these, 54% had locoregional relapse. High-grade, positive margin, large tumor size and stage III/IV were associated with worse relapse-free survival on multivariate analysis. Locoregional relapse occurred among patients with tumor size >7-</ = 10 cm (22%), >10 cm (35%), stage III/IV (31%), grade III/IV (26%), renal vein invasion (22%), perinephric fat invasion (30%), </ = 7 cm plus grade III/IV (15%), >7 cm plus grade I/II (21%), >7 cm plus grade III/IV (48%), stage III/IV plus grade I/II (24%) and stage III/IV plus grade III/IV (45%). Conclusion: We were able to discern risk factors (individual or in combination) associated with increased risk of locoregional relapse after radical nephrectomy for renal cell carcinoma. This could help distinguish patients who may benefit from adjuvant locoregionally directed therapy.

Original languageEnglish (US)
JournalAsia-Pacific Journal of Clinical Oncology
StateAccepted/In press - Jan 1 2017


  • Grade
  • Locoregional relapse
  • Radical nephrectomy
  • Renal cell carcinoma
  • Size

ASJC Scopus subject areas

  • Oncology


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