Risk factors for development of methicillin-resistant Staphylococcus aureus infection among colonized patients

Vivek Ramarathnam, Brendan De Marco, Anthony Ortegon, Dale Kemp, James Luby, Pranavi Sreeramoju

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: This study was conducted to identify clinical factors associated with development of infection caused by methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients with nasal MRSA colonization. Methods: We conducted a prospective cohort with nested case-control study at a 672-bed, public, academic hospital in Dallas, Texas. The study duration was from January 1, 2008, to July 28, 2009. From the cohort of patients who had presence of nasal colonization with MRSA at admission, we identified patients who developed subsequent infection with MRSA during a 3-month period. We compared these patients (cases) with colonized patients who remained uninfected (controls; 2 controls per case). We collected demographic and clinical data and performed statistical analyses. Results: During the 19-month study period, 426 patients were found to have nasal colonization with MRSA. Of these, 36 (8.5%) developed a subsequent infection with MRSA within 3 months. When these 36 cases were compared with 72 controls, the factors independently associated with the development of subsequent infection were development of pressure ulcer during hospital stay (adjusted odds ratio, 5.82; 95% confidence interval: 2.21-15.31; P value =.000) and preadmission steroid therapy (adjusted odds ratio, 13.2; 95% confidence interval: 2.44-70.97; P value =.003). Conclusion: History of steroid therapy prior to admission and development of pressure ulcer are associated with increased risk of subsequent MRSA infection in patients nasally colonized with MRSA.

Original languageEnglish (US)
Pages (from-to)625-628
Number of pages4
JournalAmerican Journal of Infection Control
Issue number7
StatePublished - Jul 2013


  • Active Surveillance Program
  • Hospital infection control
  • MRSA epidemiology
  • Nasal colonization
  • Observational study

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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