Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus

Tarek Sawas; Saam Dilmaghani; Lovekirat Dhaliwal; Kenneth K. Wang; Prasad G. Iyer; David A. Katzka

doi:10.14309/ajg.0000000000001001

Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus

Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

INTRODUCTION: It is assumed that screening risk factors for Barrett's esophagus (BE) and prevalent esophageal adenocarcinoma (EAC) are the same. METHODS: A matched case-control study comparing risk factors between EAC and BE was performed. RESULTS: In 1,356 patients (678 with EAC and 678 with BE), heartburn (52.7%), diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome were less common in EAC (52.7, 29.2, 45.7, 48.2, 12, and 28.5%, resp.) compared with BE (84.5, 37.6, 82.2, 64.6, 18.4, and 44.1%, P < 0.01). Mean alanine aminotransferase and HgA1c levels were also significantly lower in EAC compared with BE. DISCUSSION: Optimal strategies for screening for prevalent EAC may be different than that for BE.

Original language	English (US)
Pages (from-to)	198-201
Number of pages	4
Journal	The American Journal of Gastroenterology
Volume	116
Issue number	1
DOIs	https://doi.org/10.14309/ajg.0000000000001001
State	Published - Jan 1 2021

ASJC Scopus subject areas

Hepatology
Gastroenterology

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title = "Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus",

abstract = "INTRODUCTION: It is assumed that screening risk factors for Barrett's esophagus (BE) and prevalent esophageal adenocarcinoma (EAC) are the same. METHODS: A matched case-control study comparing risk factors between EAC and BE was performed. RESULTS: In 1,356 patients (678 with EAC and 678 with BE), heartburn (52.7%), diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome were less common in EAC (52.7, 29.2, 45.7, 48.2, 12, and 28.5%, resp.) compared with BE (84.5, 37.6, 82.2, 64.6, 18.4, and 44.1%, P < 0.01). Mean alanine aminotransferase and HgA1c levels were also significantly lower in EAC compared with BE. DISCUSSION: Optimal strategies for screening for prevalent EAC may be different than that for BE.",

author = "Tarek Sawas and Saam Dilmaghani and Lovekirat Dhaliwal and Wang, {Kenneth K.} and Iyer, {Prasad G.} and Katzka, {David A.}",

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T1 - Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus

AU - Sawas, Tarek

AU - Dilmaghani, Saam

AU - Dhaliwal, Lovekirat

AU - Wang, Kenneth K.

AU - Iyer, Prasad G.

AU - Katzka, David A.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - INTRODUCTION: It is assumed that screening risk factors for Barrett's esophagus (BE) and prevalent esophageal adenocarcinoma (EAC) are the same. METHODS: A matched case-control study comparing risk factors between EAC and BE was performed. RESULTS: In 1,356 patients (678 with EAC and 678 with BE), heartburn (52.7%), diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome were less common in EAC (52.7, 29.2, 45.7, 48.2, 12, and 28.5%, resp.) compared with BE (84.5, 37.6, 82.2, 64.6, 18.4, and 44.1%, P < 0.01). Mean alanine aminotransferase and HgA1c levels were also significantly lower in EAC compared with BE. DISCUSSION: Optimal strategies for screening for prevalent EAC may be different than that for BE.

AB - INTRODUCTION: It is assumed that screening risk factors for Barrett's esophagus (BE) and prevalent esophageal adenocarcinoma (EAC) are the same. METHODS: A matched case-control study comparing risk factors between EAC and BE was performed. RESULTS: In 1,356 patients (678 with EAC and 678 with BE), heartburn (52.7%), diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome were less common in EAC (52.7, 29.2, 45.7, 48.2, 12, and 28.5%, resp.) compared with BE (84.5, 37.6, 82.2, 64.6, 18.4, and 44.1%, P < 0.01). Mean alanine aminotransferase and HgA1c levels were also significantly lower in EAC compared with BE. DISCUSSION: Optimal strategies for screening for prevalent EAC may be different than that for BE.

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Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus

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