TY - GEN
T1 - Revealing differences in anatomical remodelling of the systemic right ventricle
AU - Zacur, Ernesto
AU - Wong, James
AU - Razavi, Reza
AU - Geva, Tal
AU - Greil, Gerald
AU - Lamata, Pablo
N1 - Funding Information:
This study has received funding by the Department of Health through the NIHR comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust, the Centre of Excellence in Medical Engineering (funded by the Wellcome Trust and EPSRC; grant number WT 088641/Z/09/Z) as well as the BHF Centre of Excellence (British Heart Foundation award RE/08/03). PL holds a Sir Henry Dale Fellowship funded jointly by the Wellcome Trust and the Royal Society (grant no. 099973/Z/12/Z).
Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - Cardiac remodelling, which refers to the change of the shape and size of the myocardium, is an adaptive response to developmental, disease and surgical processes. Traditional metrics of length, volume, aspect ratio or wall thickness are used in the clinic and in medical research, but have limited capabilities to describe complex structures such as the shape of cardiac ventricles. In this work we present an example of how computational analysis of cardiac anatomy can reveal more detailed description of developmental and remodelling patterns. The clinical problem is the analysis of the impact of two different surgical palliation techniques for hypoplastic left heart syndrome. Construction of a computational atlas and the statistical description of its variability are performed from the short axis stack of 128 subjects. Results unveil, for the first time in the literature, the differences in remodelling of the systemic right ventricle depending on the surgical palliation technique.
AB - Cardiac remodelling, which refers to the change of the shape and size of the myocardium, is an adaptive response to developmental, disease and surgical processes. Traditional metrics of length, volume, aspect ratio or wall thickness are used in the clinic and in medical research, but have limited capabilities to describe complex structures such as the shape of cardiac ventricles. In this work we present an example of how computational analysis of cardiac anatomy can reveal more detailed description of developmental and remodelling patterns. The clinical problem is the analysis of the impact of two different surgical palliation techniques for hypoplastic left heart syndrome. Construction of a computational atlas and the statistical description of its variability are performed from the short axis stack of 128 subjects. Results unveil, for the first time in the literature, the differences in remodelling of the systemic right ventricle depending on the surgical palliation technique.
KW - Computational anatomy
KW - Discriminative analysis
KW - Statistical shape analysis
KW - Systemic right ventricle
UR - http://www.scopus.com/inward/record.url?scp=84949981626&partnerID=8YFLogxK
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U2 - 10.1007/978-3-319-20309-6_12
DO - 10.1007/978-3-319-20309-6_12
M3 - Conference contribution
AN - SCOPUS:84949981626
SN - 9783319203089
SN - 9783319203089
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 99
EP - 107
BT - Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings
A2 - van Assen, Hans
A2 - Bovendeerd, Peter
A2 - van Assen, Hans
A2 - Bovendeerd, Peter
A2 - Delhaas, Tammo
A2 - Delhaas, Tammo
PB - Springer Verlag
T2 - 8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015
Y2 - 25 June 2015 through 27 June 2015
ER -