Abstract
Belatacept use has been constrained by higher rates of acute rejection. We hypothesized that belatacept with low-dose rATG and initial mycophenolate maintenance with conversion to everolimus at 1 month post-transplant ± corticosteroids would improve efficacy and maintain safety. Retrospective single-center analysis of the first 44 low immunologic risk kidney transplant recipients treated with this regimen. The cohort was 59% male, mean age at transplant of 57 years. Diabetes was the most common cause of ESRD (39%). The mean 1-year eGFR was 61.4 (SD 18.4) mL/min/1.73 m2. There were five acute cellular rejections (11.4%) that occurred in patients who had changed from everolimus to mycophenolate mofetil due to side effects. Thirty-two percent developed BK viremia and 12% developed CMV viremia. There were no cases of PTLD. A novel belatacept regimen with rATG induction and maintenance everolimus demonstrated a low acute rejection rate and maintained an excellent 1-year eGFR.
Original language | English (US) |
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Article number | e13042 |
Journal | Clinical Transplantation |
Volume | 31 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2017 |
Externally published | Yes |
Keywords
- Fusion proteins: belatacept, immunosuppressant
- Immunosuppressant
- mechanistic target of rapamycin: everolimus, immunosuppressive regimens
ASJC Scopus subject areas
- Transplantation