TY - JOUR
T1 - Resveratrol
T2 - A new potential therapeutic agent for melanoma?
AU - Pourhanifeh, Mohamad Hossein
AU - Abbaszadeh-Goudarzi, Kazem
AU - Goodarzi, Mohammad
AU - Piccirillo, Sara Grazia Maria
AU - Shafiee, Alimohammad
AU - Hajighadimi, Sarah
AU - Moradizarmehri, Sanaz
AU - Asemi, Zatollah
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Melanoma is the most life-threatening and aggressive class of skin malignancies. The inci-dence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanoma treatments such as chemotherapy, and the 5-year survival rate of cases with melanoma who have a metastatic form of the disease is less than 10%. The contributing role of apoptosis, angio-genesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approaches that could enhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. Herein, for the first time, we summarize the current knowledge of anti-cancerous activities of resvera-trol in melanoma.
AB - Melanoma is the most life-threatening and aggressive class of skin malignancies. The inci-dence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanoma treatments such as chemotherapy, and the 5-year survival rate of cases with melanoma who have a metastatic form of the disease is less than 10%. The contributing role of apoptosis, angio-genesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approaches that could enhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. Herein, for the first time, we summarize the current knowledge of anti-cancerous activities of resvera-trol in melanoma.
KW - Angiogenesis
KW - Apoptosis
KW - Melanoma
KW - Natural compounds
KW - Resveratrol
KW - Therapy
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U2 - 10.2174/0929867326666191212101225
DO - 10.2174/0929867326666191212101225
M3 - Review article
C2 - 31830881
AN - SCOPUS:85097743801
SN - 0929-8673
VL - 28
SP - 687
EP - 711
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 4
ER -