Abstract
Ankylosing spondylitis (AS) is very strongly associated with the class I major histocompatibility (MHC) antigen HLA-B27. Because class I MHC antigens function as restricting elements recognized by T cell antigen receptors, we sought to determine if there is preferential association between AS and particular T cell (TcR) alleles. In 49 patients with AS and 23 controls, we determined the frequencies of restriction fragment length polymorphisms linked to genes encoding the TcR α and β chain constant regions. There was no significant difference between patients with AS and controls with respect to the frequencies of possible TcR genotypes. Although T cells may play a role in the pathogenesis of AS, these results provide no evidence for a distinctive germline T cell repertoire associated with AS.
Original language | English (US) |
---|---|
Pages (from-to) | 1115-1118 |
Number of pages | 4 |
Journal | Journal of Rheumatology |
Volume | 15 |
Issue number | 7 |
State | Published - 1988 |
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology