@article{6252e04c37084e858ec989623f09480b,
title = "Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing",
abstract = "The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The molecular players that can enhance OPC differentiation or rejuvenate OPCs are unclear. Here we show that, in mouse OPCs, nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing. When we supplement β-nicotinamide mononucleotide (β-NMN), an NAD+ precursor, nuclear entry of SIRT2 in OPCs, OPC differentiation, and remyelination were rescued in aged animals. We show that the effects on myelination are mediated via the NAD+-SIRT2-H3K18Ac-ID4 axis, and SIRT2 is required for rejuvenating OPCs. Our results show that SIRT2 and NAD+ levels rescue the aged OPC differentiation potential to levels comparable to young age, providing potential targets to enhance remyelination during ageing.",
author = "Ma, {Xiao Ru} and Xudong Zhu and Yujie Xiao and Gu, {Hui Min} and Zheng, {Shuang Shuang} and Liang Li and Fan Wang and Dong, {Zhao Jun} and Wang, {Di Xian} and Yang Wu and Chenyu Yang and Wenhong Jiang and Ke Yao and Yue Yin and Yang Zhang and Chao Peng and Lixia Gao and Zhuoxian Meng and Zeping Hu and Chong Liu and Li Li and Chen, {Hou Zao} and Yousheng Shu and Zhenyu Ju and Zhao, {Jing Wei}",
note = "Funding Information: We thank the Center of Cryo-Electron Microscopy, Zhejiang University (ZJU), and the Core Facilities of ZJU School of Medicine. Particular thanks to Drs. Xing Zhang, Mengsheng Qiu, Hao Huang, Hui Fu and Mrs. Sanling Wu. Thanks to Ruo-Tong Zhao for providing language editing. This work was supported by the National Key R&D Program of China (grants 2017YFA0104900, 2021ZD0201700 and BZZ19J005 to J.-W.Z., and grant 2021ZD0202501 to Y.S.), and the National Natural Science Foundation of China (grants 81971144 and 81571170 to J.-W.Z., and grants 92049304 and 82030039 to Z.J.), and the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (grant 2021-I2M-1-050) to H.-Z.C. Funding Information: We thank the Center of Cryo-Electron Microscopy, Zhejiang University (ZJU), and the Core Facilities of ZJU School of Medicine. Particular thanks to Drs. Xing Zhang, Mengsheng Qiu, Hao Huang, Hui Fu and Mrs. Sanling Wu. Thanks to Ruo-Tong Zhao for providing language editing. This work was supported by the National Key R&D Program of China (grants 2017YFA0104900, 2021ZD0201700 and BZZ19J005?to J.-W.Z., and grant?2021ZD0202501 to Y.S.), and the National Natural Science Foundation of China (grants 81971144 and 81571170 to J.-W.Z.,?and grants 92049304 and 82030039 to Z.J.), and the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (grant?2021-I2M-1-050) to H.-Z.C. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41467-022-28844-1",
language = "English (US)",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}