Resting state functional MRI reveals abnormal network connectivity in orthostatic tremor

Julian Benito-Leon, Elan D. Louis, Eva Manzanedo, Juan Antonio Hernandez-Tamames, Juan Alvarez-Linera, Jose Antonio Molina-Arjona, Michele Matarazzo, Juan Pablo Romero, Cristina Dominguez-Gonzalez, Angela Domingo-Santos, Alvaro Sanchez-Ferro

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Very little is known about the pathogenesis of orthostatic tremor (OT). We have observed that OT patientsmight have deficits in specific aspects of neuropsychological function, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests a possible involvement of frontocerebellar circuits. We examined whether resting-state functional magnetic resonance imaging (fMRI) might provide further insights into the pathogenesis on OT. Resting-state fMRI data in 13 OT patients (11 women and 2 men) and 13 matched healthy controls were analyzed using independent component analysis, in combination with a "dual-regression" technique, to identify group differences in several resting-state networks (RSNs). All participants also underwent neuropsychological testing during the same session. Relative to healthy controls, OT patients showed increased connectivity in RSNs involved in cognitive processes (default mode network [DMN] and frontoparietal networks), and decreased connectivity in the cerebellumand sensorimotor networks.Changes in network integrity were associated not onlywith duration (DMN and medial visual network), but also with cognitive function. Moreover, in at least 2 networks (DMN and medial visual network), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, visual memory, and language). In this exploratory study, we observed selective impairments ofRSNs inOT patients. This and other future resting-state fMRI studiesmight provide a novelmethod to understand the pathophysiological mechanisms of motor and nonmotor features of OT.

Original languageEnglish (US)
Article numbere4310
JournalMedicine (United States)
Issue number29
StatePublished - Jul 26 2016
Externally publishedYes


  • Case-control study
  • Functional connectivity
  • Magnetic resonance imaging
  • Orthostatic tremor

ASJC Scopus subject areas

  • General Medicine


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