Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

Zhiqiang Ma; Xiaolei Wang; Xiao Wang; Rodrigo A. Rodriguez; Curtis E. Moore; Shuanhu Gao; Xianghui Tan; Yuyong Ma; Arnold L. Rheingold; Phil S. Baran; Chuo Chen

doi:10.1126/science.aaa9626

Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

Zhiqiang Ma, Xiaolei Wang, Xiao Wang, Rodrigo A. Rodriguez, Curtis E. Moore, Shuanhu Gao, Xianghui Tan, Yuyong Ma, Arnold L. Rheingold, Phil S. Baran, Chuo Chen

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Abstract

Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.

Original language	English (US)
Pages (from-to)	149c
Journal	Science
Volume	349
Issue number	6244
DOIs	https://doi.org/10.1126/science.aaa9626
State	Published - Jul 10 2015

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title = "Response to Comment on {"}Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence{"}",

abstract = "Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these {"}congeners{"} are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.",

author = "Zhiqiang Ma and Xiaolei Wang and Xiao Wang and Rodriguez, {Rodrigo A.} and Moore, {Curtis E.} and Shuanhu Gao and Xianghui Tan and Yuyong Ma and Rheingold, {Arnold L.} and Baran, {Phil S.} and Chuo Chen",

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T1 - Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

AU - Ma, Zhiqiang

AU - Wang, Xiaolei

AU - Wang, Xiao

AU - Rodriguez, Rodrigo A.

AU - Moore, Curtis E.

AU - Gao, Shuanhu

AU - Tan, Xianghui

AU - Ma, Yuyong

AU - Rheingold, Arnold L.

AU - Baran, Phil S.

AU - Chen, Chuo

PY - 2015/7/10

Y1 - 2015/7/10

N2 - Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.

AB - Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.

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Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

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