TY - JOUR
T1 - Respiratory function monitoring during neonatal resuscitation
T2 - A systematic review
AU - Fuerch, Janene H.
AU - Thio, Marta
AU - Halamek, Louis P.
AU - Liley, Helen G.
AU - Wyckoff, Myra H.
AU - Rabi, Yacov
N1 - Funding Information:
We thank and acknowledge Christopher Stave (Stanford University School of Medicine Information Services Librarian) for developing the search strategy. Funding: The International Liaison Committee on Resuscitation provided support that included access to software platforms and teleconferencing. Besides authors Drs. Rabi, Liley and Wyckoff, the following additional International Liaison Committee on Resuscitation Neonatal Life Support Task Force members provided input on the review protocol, the interpretation of the results, and the manuscript as experts in neonatal resuscitation: • Daniela T. Costa-Nobre, Federal University of São Paulo, São Paulo, Brazil. • Peter G. Davis, The Royal Women's Hospital, Victoria Australia. • Fernanda de Almeida, Federal University of São Paulo, São Paulo, Brazil. • Walid El-Naggar, Dalhousie University, Halifax, Nova Scotia, Canada; • Jorge G. Fabres, Universidad Catolica de Chile, Santiago, Chile; • Joe Fawke, Leicester Royal Infirmary, Leicester, UK; • Elizabeth E. Foglia, University of Pennsylvania, Philadelphia, Pennsylvania, USA; • Ruth Guinsburg, Federal University of São Paulo, São Paulo, Brazil. • Tetsuya Isayama, National Research Institute for Child Health and Development, Tokyo, Japan. • Vishal S. Kapadia, University of Texas Southwestern Medical Center, Dallas, Texas, USA; • Mandira D. Kawakami, Federal University of Sao Paulo, Sao Paulo, SP, Brazil; • Han-Suk Kim, Seoul National University College of Medicine, Seoul, Korea; • Henry C. Lee, Stanford University, Stanford, California, USA; • R. John Madar, University Hospitals Plymouth, Plymouth, UK. • Chris J.D. McKinlay, University of Auckland, Auckland, New Zealand; • Firdose L. Nakwa, University of Witwatersrand, South Africa. • Jeff M. Perlman, Weill Cornell Medicine, New York, New York USA. • Yacov Rabi, University of Calgary, Calgary, Alberta, Canada; • Charles C. Roehr, John Radcliffe Hospital, Oxford University Hospitals, UK; • Mario Rüdiger, Technische Universität Dresden, Dresden, Germany. • Georg M. Schmölzer, University of Alberta, Edmonton, Canada; • Takahiro Sugiura, Toyohashi Municipal Hospital, Toyohashi, Aichi, Japan; • Daniele Trevisanuto, University of Padua, Padua, Italy. • Gary M. Weiner, University of Michigan, Ann Arbor, Michigan, USA. • Jonathan P. Wyllie, James Cook University Hospital, Middlesbrough, United Kingdom., Article Summary:, JF and YR conducted the literature search and article screening, MT completed full-text review to resolve any disagreements. JF, YR, LH completed bias assessment and GRADE analysis. All authors contributed to and approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Publisher Copyright:
© 2022 The Authors
PY - 2022/12
Y1 - 2022/12
N2 - Aim: Positive pressure ventilation via a facemask is critical in neonatal resuscitation, but frequently results in mask leak, obstruction, and inadequate respiratory support. This systematic review aimed to determine whether the display of respiratory function monitoring improved resuscitation or clinical outcomes. Methods: Randomized controlled trials comparing outcomes when respiratory function monitoring was displayed versus not displayed for newborns requiring positive pressure ventilation at birth were selected and from databases (last search August 2022), and assessed for risk of bias using Cochrane Risk of Bias Tools for randomized control trials. The study was registered in the Prospective Register of Systematic Reviews. Grading of Recommendations, Assessment, Development and Evaluations was used to assess the certainty of evidence. Treatment recommendations were approved by the Neonatal Life Support Task Force of the International Liaison Committee on Resuscitation. Results reported primary and secondary outcomes and included resuscitation and clinical outcomes. Results: Of 2294 unique articles assessed for eligibility, three randomized controlled trials were included (observational studies excluded) (n = 443 patients). For predefined resuscitation and clinical outcomes, these studies either did not report the primary outcome (time to heart rate ≥ 100 bpm from birth), had differing reporting methods (achieving desired tidal volumes, significant mask leak) or did not find significant differences (intubation rate, air leaks, death before hospital discharge, severe intraventricular hemorrhage, chronic lung disease). Limitations included limited sample size for critical outcomes, inconsistent definitions amongst studies and unreported long-term outcomes. Conclusion: Although respiratory function monitoring has been utilized in clinical care, there is currently insufficient evidence to suggest its benefit for newborn infants receiving respiratory support for resuscitation at birth. Registration: PROSPERO CRD42021278169 (registered November 27, 2021). Funding: The International Liaison Committee on Resuscitation provided support that included access to software platforms and teleconferencing.
AB - Aim: Positive pressure ventilation via a facemask is critical in neonatal resuscitation, but frequently results in mask leak, obstruction, and inadequate respiratory support. This systematic review aimed to determine whether the display of respiratory function monitoring improved resuscitation or clinical outcomes. Methods: Randomized controlled trials comparing outcomes when respiratory function monitoring was displayed versus not displayed for newborns requiring positive pressure ventilation at birth were selected and from databases (last search August 2022), and assessed for risk of bias using Cochrane Risk of Bias Tools for randomized control trials. The study was registered in the Prospective Register of Systematic Reviews. Grading of Recommendations, Assessment, Development and Evaluations was used to assess the certainty of evidence. Treatment recommendations were approved by the Neonatal Life Support Task Force of the International Liaison Committee on Resuscitation. Results reported primary and secondary outcomes and included resuscitation and clinical outcomes. Results: Of 2294 unique articles assessed for eligibility, three randomized controlled trials were included (observational studies excluded) (n = 443 patients). For predefined resuscitation and clinical outcomes, these studies either did not report the primary outcome (time to heart rate ≥ 100 bpm from birth), had differing reporting methods (achieving desired tidal volumes, significant mask leak) or did not find significant differences (intubation rate, air leaks, death before hospital discharge, severe intraventricular hemorrhage, chronic lung disease). Limitations included limited sample size for critical outcomes, inconsistent definitions amongst studies and unreported long-term outcomes. Conclusion: Although respiratory function monitoring has been utilized in clinical care, there is currently insufficient evidence to suggest its benefit for newborn infants receiving respiratory support for resuscitation at birth. Registration: PROSPERO CRD42021278169 (registered November 27, 2021). Funding: The International Liaison Committee on Resuscitation provided support that included access to software platforms and teleconferencing.
KW - Grading of Recommendations, Assessment, Development and Evaluations (GRADE)
KW - International Liaison Committee on Resuscitation (ILCOR)
KW - Neonatal Life Support Task Force (NLS TF)
KW - Neonatal resuscitation
KW - Positive pressure ventilation (PPV)
KW - Preferred Reporting Items for Systematic Reviews and meta-analyses (PRISMA)
KW - Respiratory function monitoring
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U2 - 10.1016/j.resplu.2022.100327
DO - 10.1016/j.resplu.2022.100327
M3 - Review article
C2 - 36425449
AN - SCOPUS:85141990344
SN - 2666-5204
VL - 12
JO - Resuscitation Plus
JF - Resuscitation Plus
M1 - 100327
ER -