TY - JOUR
T1 - Resisting viral infection
T2 - The gene by gene approach
AU - Moresco, Eva Marie Y
AU - Beutler, Bruce
PY - 2011/12
Y1 - 2011/12
N2 - This review focuses on genes required for resistance to mouse cytomegalovirus (MCMV), as identified through unbiased genetic screening. Components of the developmental, sensing, and effector pathways, functioning in multiple cell types, were detected by infecting 22,000 G3 mutant mice with MCMV at an inoculum easily contained by WT animals. Merging these findings with discoveries from hypothesis-based studies, we present a cohesive picture of the essential elements utilized by the mouse innate immune system to counter MCMV. We believe that many breakthrough discoveries will yet be made using a classical genetic approach.
AB - This review focuses on genes required for resistance to mouse cytomegalovirus (MCMV), as identified through unbiased genetic screening. Components of the developmental, sensing, and effector pathways, functioning in multiple cell types, were detected by infecting 22,000 G3 mutant mice with MCMV at an inoculum easily contained by WT animals. Merging these findings with discoveries from hypothesis-based studies, we present a cohesive picture of the essential elements utilized by the mouse innate immune system to counter MCMV. We believe that many breakthrough discoveries will yet be made using a classical genetic approach.
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U2 - 10.1016/j.coviro.2011.10.005
DO - 10.1016/j.coviro.2011.10.005
M3 - Review article
C2 - 22440911
AN - SCOPUS:82955187324
SN - 1879-6257
VL - 1
SP - 513
EP - 518
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 6
ER -