Abstract
Vitamin A regulates skin immunity via unknown mechanisms. Harris et al. show that RELMα is an antimicrobial protein expressed by epidermal cells that shapes resident skin bacterial communities and limits skin infection. RELMα is induced by dietary vitamin A and mediates vitamin-A-dependent resistance to skin infection.
Original language | English (US) |
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Pages (from-to) | 777-788.e8 |
Journal | Cell Host and Microbe |
Volume | 25 |
Issue number | 6 |
DOIs | |
State | Published - Jun 12 2019 |
Keywords
- antimicrobial protein
- bacteria
- innate immunity
- microbiome
- skin
- skin infection
- vitamin A
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology