Resistant hypertension: What to do after trying 'the usual'

Norman M Kaplan

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Hypertension is considered to be 'resistant' if a patient's diastolic blood pressure remains above 90 mm Hg despite the use of full doses of three antihypertensive medications. The most likely causes of ineffective blood pressure control include inadequate drug regimens and patient factors such as noncompliance, obesity, cigarette smoking, alcoholism, and 'office hypertension.' The two most common physiologic causes of resistance are volume overload and secondary hypertension, particularly renovascular disease. When suspicion of renovascular hypertension is high, immediate renal arteriography is indicated. In most patients, however, the less invasive captopril challenge is an adequate screening test. Most hypertensive patients with true resistance can be treated by altering their medication regimen.

Original languageEnglish (US)
Pages (from-to)24-25+29
Issue number5
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Geriatrics and Gerontology


Dive into the research topics of 'Resistant hypertension: What to do after trying 'the usual''. Together they form a unique fingerprint.

Cite this