Resident viruses and their interactions with the immune system

Breck A. Duerkop, Lora V. Hooper

Research output: Contribution to journalReview articlepeer-review

213 Scopus citations


The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota-immune system interactions for human health.

Original languageEnglish (US)
Pages (from-to)654-659
Number of pages6
JournalNature immunology
Issue number7
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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