Residence at 3,800-m altitude for 5 mo in growing dogs enhances lung diffusing capacity for oxygen that persists at least 2.5 years

Connie C W Hsia, Robert L. Johnson, Paul McDonough, D. Merrill Dane, Myresa D. Hurst, Jennifer L. Fehmel, Harrieth E. Wagner, Peter D. Wagner

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Mammals native to high altitude (HA) exhibit larger lung volumes than their lowland counterparts. To test the hypothesis that adaptation induced by HA residence during somatic maturation improves pulmonary gas exchange in adulthood, male foxhounds born at sea level (SL) were raised at HA (3,800 m) from 2.5 to 7.5 mo of age and then returned to SL prior to somatic maturity while their littermates were simultaneously raised at SL. Following return to SL, all animals were trained to run on a treadmill; gas exchange and hemodynamics were measured 2.5 years later at rest and during exercise while breathing 21% and 13% O2. The multiple inert gas elimination technique was employed to estimate ventilation-perfusion (V̇A/Q̇) distributions and lung diffusing capacity for O2 (DLO2). There were no significant intergroup differences during exercise breathing 21% O2. During exercise breathing 13% O2, peak O2 uptake and V̇A/Q̇ distributions were similar between groups but arterial pH, base excess, and O2 saturation were higher while peak lactate concentration was lower in animals raised at HA than at SL. At a given exercise intensity, alveolar-arterial O2 tension gradient (A-aDO2) attributable to diffusion limitation was lower while DLO2 was 12-25% higher in HA-raised animals. Mean systemic arterial blood pressure was also lower in HA-raised animals; mean pulmonary arterial pressures were similar. We conclude that 5 mo of HA residence during maturation enhances long-term gas exchange efficiency and DLO2 without impacting V̇A/Q̇ inequality during hypoxic exercise at SL.

Original languageEnglish (US)
Pages (from-to)1448-1455
Number of pages8
JournalJournal of applied physiology
Issue number4
StatePublished - Apr 2007


  • Exercise
  • Hypoxia
  • Multiple inert gas elimination technique
  • Oxygen diffusing capacity
  • Ventilation-perfusion distribution

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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