@article{0ccbdbc8fa184c87bb2fc7567210d04e,
title = "Research and therapeutics-traditional and emerging therapies in systemic lupus erythematosus",
abstract = "This review summarizes traditional and emerging therapies for SLE. Evidence suggests that the heterogeneity of SLE is a crucial aspect contributing to the failure of large clinical trials for new targeted therapies. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science are predicted to enable accelerated progress towards improved SLE diagnosis and personalized approaches to treatment.",
keywords = "B cells, Biological therapies, Clinical trials, Immunotherapy, Methods, Systemic lupus erythematosus and autoimmunity",
author = "Davis, {Laurie S.} and Reimold, {Andreas M.}",
note = "Funding Information: Disclosure statement: A.M.R. is an investigator for clinical trials sponsored by Bristol-Myers Squibb, Genentech, GlaxoSmithKline and Johnson and Johnson. L.S.D. is supported by funding from the Alliance for Lupus Research (ALR) and National Institutes of Health grants AR067625 (PI, Satterthwaite) and AI122720 (PI, Satterthwaite). Funding Information: We thank Dr A. Satterthwaite for helpful comments on B cell biology. No specific funding was received from any bodies in the public, commercial or not-for-profit sectors to carry out the work described in this manuscript. A.M.R. is an investigator for clinical trials sponsored by Bristol-Myers Squibb, Genentech, GlaxoSmithKline and Johnson and Johnson. L.S.D. is supported by funding from the Alliance for Lupus Research (ALR) and National Institutes of Health grants AR067625 (PI, Satterthwaite) and AI122720 (PI, Satterthwaite). Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.",
year = "2017",
month = apr,
doi = "10.1093/rheumatology/kew417",
language = "English (US)",
volume = "56",
pages = "I100--I113",
journal = "Rheumatology (United Kingdom)",
issn = "1462-0324",
publisher = "Oxford University Press",
}