Abstract
A prior transient hindlimb ischemia/reperfusion (I/R) insult decreased acute lung injury in rats subsequently treated with cobra venom factor. I/R-mediated protection was associated with erythrocyte hemolysis, increased plasma catalase activity, and increased plasma hydrogen peroxide scavenging activity. In contrast, hindlimb I/R did not increase lung catalase activity, and large amounts of injected catalase were required to increase lung catalase activity. The results suggest that limited I/R in one organ can induce systemic processes that may decrease a subsequent O2 metabolite-mediated injury in another distant organ. The mechanism may involve release of catalase from hemolyzed erythrocytes at levels that are not sufficient to measurably increase total lung catalase activity.
Original language | English (US) |
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Pages (from-to) | 352-358 |
Number of pages | 7 |
Journal | Journal of Laboratory and Clinical Medicine |
Volume | 118 |
Issue number | 4 |
State | Published - 1991 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine