Renal Stones of Calcium Phosphate: Physicochemical Basis for Their Formation

C. Y. Pak, E. C. Diller, G. W. Smith, E. S. Howe

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The activity product of Ca2+ and HPO4 2− was calculated for the urine before and after incubation with brushite (CaHPO4 · 2H2O). This permitted an estimation of the degree of saturation of urine in terms of Ca2+ and HPO4 2−. The urine of patients with idiopathic hypercalciuria was supersaturated with respect to brushite at all pH. However, the urine of normocalciuric subjects with stone was supersaturated only at high urinary pH.

Original languageEnglish (US)
Pages (from-to)753-757
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Mar 1969

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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