TY - JOUR
T1 - Renal oxalate excretion following oral oxalate loads in patients with ileal disease and with renal and absorptive hypercalciurias. Effect of calcium and magnesium
AU - Barilla, Donald E.
AU - Notz, Constance
AU - Kennedy, Diedre
AU - Pak, Charles Y C
N1 - Funding Information:
From the Section of Mineral Metabolism, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas. This study was supported by U.S. Public Health Service Grants l-ROl-AM-16061 and 5 MOlRR00633. Requests for reprints should be addressed to Dr Charles Y. C. Pak. The University of Texas, Health Sciences Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235. Manuscript accepted August 16. 1977.
PY - 1978/4
Y1 - 1978/4
N2 - Intestinal absorption of oxalate was assessed indirectly from the increase in renal oxalate excretion following the oral administration of 5 mmol of stable oxalate. When sodium oxalate alone was given without divalent cations to patients in the fasting state, the urinary oxalate increased promptly (within 2 hours). The increase was more prominent and sustained in those with ileal disease (ileal resection or jujunoileal bypass); thus, 35 per cent of the orally administered oxalate eventually appeared in the urine in the group with ileal disease, 8 per cent in the group with stones (renal and absorptive hypercalciurias) and 9 per cent in the control group. This hyperexcretion of oxalate could be largely, but not totally, ameliorated by the concurrent oral administration of divalent cations. Although urinary oxalate decreased significantly following the oral administration of calcium or magnesium, hyperoxaluria persisted in most patients. The results suggested that the hyperabsorption of oxalate in ileal disease cannot be accounted for solely by an increased absorbable oxalate pool associated with calcium-fatty acid complexation. Moreover, although urinary oxalate decreased, urinary calcium increased concurrently when either calcium or magnesium was given. Thus, there was no significant change or increase in the urinary state of saturation with respect to calcium oxalate.
AB - Intestinal absorption of oxalate was assessed indirectly from the increase in renal oxalate excretion following the oral administration of 5 mmol of stable oxalate. When sodium oxalate alone was given without divalent cations to patients in the fasting state, the urinary oxalate increased promptly (within 2 hours). The increase was more prominent and sustained in those with ileal disease (ileal resection or jujunoileal bypass); thus, 35 per cent of the orally administered oxalate eventually appeared in the urine in the group with ileal disease, 8 per cent in the group with stones (renal and absorptive hypercalciurias) and 9 per cent in the control group. This hyperexcretion of oxalate could be largely, but not totally, ameliorated by the concurrent oral administration of divalent cations. Although urinary oxalate decreased significantly following the oral administration of calcium or magnesium, hyperoxaluria persisted in most patients. The results suggested that the hyperabsorption of oxalate in ileal disease cannot be accounted for solely by an increased absorbable oxalate pool associated with calcium-fatty acid complexation. Moreover, although urinary oxalate decreased, urinary calcium increased concurrently when either calcium or magnesium was given. Thus, there was no significant change or increase in the urinary state of saturation with respect to calcium oxalate.
UR - http://www.scopus.com/inward/record.url?scp=0018090228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018090228&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(78)90576-4
DO - 10.1016/0002-9343(78)90576-4
M3 - Article
C2 - 645724
AN - SCOPUS:0018090228
SN - 0002-9343
VL - 64
SP - 579
EP - 585
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 4
ER -