TY - JOUR
T1 - Renal metanephric adenoma with previously unreported cytogenetic abnormalities
T2 - Case report and review of the literature
AU - Rakheja, Dinesh
AU - Lian, Fangru
AU - Tomlinson, Gail E.
AU - Ewalt, David H.
AU - Schultz, Roger A.
AU - Margraf, Linda R.
PY - 2005/4/1
Y1 - 2005/4/1
N2 - We report a case of a renal metanephric adenoma in a 10-year-old boy, in which cytogenetic analysis showed a balanced translocation, t(9;15)(p24;q24) and a balanced paracentric inversion of chromosome 12, inv(12)(q13q15). Immunohistochemically, the tumor showed diffuse reactivity for cytokeratin AE1/AE3, CAM5.2, CD57, and WT1; patchy reactivity for CD56; and focal reactivity for cytokeratin 7, epithelial membrane antigen, and CD10. Tumor cells were entirely nonreactive for α-methyl acyl coenzyme A racemase. Published cytogenetic data for metanephric adenomas are limited, and this is the first report of these cytogenetic abnormalities. The involvement of the chromosome region 9p24 is particularly interesting because of the recent identification of a tumor suppressor gene, KANK (kidney ankyrin repeat-containing protein), at this locus.
AB - We report a case of a renal metanephric adenoma in a 10-year-old boy, in which cytogenetic analysis showed a balanced translocation, t(9;15)(p24;q24) and a balanced paracentric inversion of chromosome 12, inv(12)(q13q15). Immunohistochemically, the tumor showed diffuse reactivity for cytokeratin AE1/AE3, CAM5.2, CD57, and WT1; patchy reactivity for CD56; and focal reactivity for cytokeratin 7, epithelial membrane antigen, and CD10. Tumor cells were entirely nonreactive for α-methyl acyl coenzyme A racemase. Published cytogenetic data for metanephric adenomas are limited, and this is the first report of these cytogenetic abnormalities. The involvement of the chromosome region 9p24 is particularly interesting because of the recent identification of a tumor suppressor gene, KANK (kidney ankyrin repeat-containing protein), at this locus.
KW - Cytogenetics
KW - Metanephric adenoma
KW - Papillary renal cell carcinoma
KW - Wilms tumor
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U2 - 10.1007/s10024-004-7081-3
DO - 10.1007/s10024-004-7081-3
M3 - Article
C2 - 15747102
AN - SCOPUS:21244486749
SN - 1093-5266
VL - 8
SP - 218
EP - 223
JO - Pediatric and Developmental Pathology
JF - Pediatric and Developmental Pathology
IS - 2
ER -