Renal lipid metabolism abnormalities in obesity and clear cell renal cell carcinoma

Ion Alexandru Bobulescu; Laurentiu M. Pop; Chinnadurai Mani; Kala Turner; Christian Rivera; Sabiha Khatoon; Subash Kairamkonda; Raquibul Hannan; Komaraiah Palle

doi:10.3390/metabo11090608

Renal lipid metabolism abnormalities in obesity and clear cell renal cell carcinoma

Ion Alexandru Bobulescu, Laurentiu M. Pop, Chinnadurai Mani, Kala Turner, Christian Rivera, Sabiha Khatoon, Subash Kairamkonda, Raquibul Hannan, Komaraiah Palle

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits. These deposits are thought to result from lipid metabolic reprogramming occurring in tumor cells, but the exact mechanisms and implications of these metabolic alterations are incompletely understood. Obesity is an independent risk factor for clear cell renal cell carcinoma, and is also associated with lipid accumulation in noncancerous epithelial cells of the proximal tubule, where clear cell renal cell carcinoma originates. This article explores the potential link between obesity-associated renal lipid metabolic disturbances and lipid metabolic reprogramming in clear cell renal cell carcinoma, and discusses potential implications for future research.

Original language	English (US)
Article number	608
Journal	Metabolites
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/metabo11090608
State	Published - Sep 2021

Keywords

Lipotoxicity
Metabolic reprogramming
Preneoplastic changes
Tumorigenesis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology

Access to Document

10.3390/metabo11090608

Cite this

@article{f84bcf67d891478688a594c703024a7f,

title = "Renal lipid metabolism abnormalities in obesity and clear cell renal cell carcinoma",

abstract = "Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits. These deposits are thought to result from lipid metabolic reprogramming occurring in tumor cells, but the exact mechanisms and implications of these metabolic alterations are incompletely understood. Obesity is an independent risk factor for clear cell renal cell carcinoma, and is also associated with lipid accumulation in noncancerous epithelial cells of the proximal tubule, where clear cell renal cell carcinoma originates. This article explores the potential link between obesity-associated renal lipid metabolic disturbances and lipid metabolic reprogramming in clear cell renal cell carcinoma, and discusses potential implications for future research.",

keywords = "Lipotoxicity, Metabolic reprogramming, Preneoplastic changes, Tumorigenesis",

author = "Bobulescu, {Ion Alexandru} and Pop, {Laurentiu M.} and Chinnadurai Mani and Kala Turner and Christian Rivera and Sabiha Khatoon and Subash Kairamkonda and Raquibul Hannan and Komaraiah Palle",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

doi = "10.3390/metabo11090608",

language = "English (US)",

volume = "11",

journal = "Metabolites",

issn = "2218-1989",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

TY - JOUR

T1 - Renal lipid metabolism abnormalities in obesity and clear cell renal cell carcinoma

AU - Bobulescu, Ion Alexandru

AU - Pop, Laurentiu M.

AU - Mani, Chinnadurai

AU - Turner, Kala

AU - Rivera, Christian

AU - Khatoon, Sabiha

AU - Kairamkonda, Subash

AU - Hannan, Raquibul

AU - Palle, Komaraiah

PY - 2021/9

Y1 - 2021/9

N2 - Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits. These deposits are thought to result from lipid metabolic reprogramming occurring in tumor cells, but the exact mechanisms and implications of these metabolic alterations are incompletely understood. Obesity is an independent risk factor for clear cell renal cell carcinoma, and is also associated with lipid accumulation in noncancerous epithelial cells of the proximal tubule, where clear cell renal cell carcinoma originates. This article explores the potential link between obesity-associated renal lipid metabolic disturbances and lipid metabolic reprogramming in clear cell renal cell carcinoma, and discusses potential implications for future research.

AB - Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits. These deposits are thought to result from lipid metabolic reprogramming occurring in tumor cells, but the exact mechanisms and implications of these metabolic alterations are incompletely understood. Obesity is an independent risk factor for clear cell renal cell carcinoma, and is also associated with lipid accumulation in noncancerous epithelial cells of the proximal tubule, where clear cell renal cell carcinoma originates. This article explores the potential link between obesity-associated renal lipid metabolic disturbances and lipid metabolic reprogramming in clear cell renal cell carcinoma, and discusses potential implications for future research.

KW - Lipotoxicity

KW - Metabolic reprogramming

KW - Preneoplastic changes

KW - Tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=85114841423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85114841423&partnerID=8YFLogxK

U2 - 10.3390/metabo11090608

DO - 10.3390/metabo11090608

M3 - Review article

C2 - 34564424

AN - SCOPUS:85114841423

SN - 2218-1989

VL - 11

JO - Metabolites

JF - Metabolites

IS - 9

M1 - 608

ER -

Renal lipid metabolism abnormalities in obesity and clear cell renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this