Renal hemodynamic effects of ketanserin therapy in essential hypertension

C. V S Ram, D. G. Gonzalez, Norman M Kaplan, J. M. Ralakis, J. D. Henderson, C. E. Lugo, N. Zachariah

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Ketanserin is a novel agent that has been shown to be a specific 5-HT2-serotonergic antagonist. It has useful antihypertensive properties. Owing to its unique mechanism of action, it has been suggested that ketanserin may have a favorable effect on tissue blood flow during chronic therapy for hypertension. This double-blind study was designed to evaluate the acute (1 week) and chronic (8 weeks) effects of ketanse-rin on renal hemodynamic parameters and renin-aldosterone axis in patients with uncomplicated hypertension. Compared to placebo, ketanserin caused a significant blood pressure reduction at the end of the 8-week study period. Despite the reduction in systematic arterial pressure, glomerular filtration rate and renal plasma flow were preserved. Ketanserin therapy induced a slight reduction in plastna renin activity and a marginal increase in the sodium excretion. Although the results of this study are limited by the small number of patients, it appears that ketanserin may have favorable renal hemodynamic effects in uncomplicated essential hypertension.

Original languageEnglish (US)
Pages (from-to)S78-S80
JournalJournal of Cardiovascular Pharmacology
StatePublished - Jan 1 1987


  • Antihypertensive drugs
  • Glomerular filtration rate
  • Renal blood flow
  • Serotonin antagonists
  • Systemic hypertension

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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