Renal handling of calcium

Donald W. Seldin

doi:10.1159/000046292

Renal handling of calcium

Donald W. Seldin

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Ca absorption is mediated by both active and passive processes. Absorption in both proximal tubule and thick ascending limb is mainly coupled indirectly to Na absorption and is a passive process through the paracellular pathway. In the distal convoluted tubule, Ca absorption is regulated independently of Na absorption; this is the principal site of action of parathyroid hormone, calcitonin, and 1,25-(OH)₂D₃. Models for transport in proximal tubule, thick ascending limb, and distal convoluted tubule afford attractive explanations for the influence on Ca transport of effective arterial blood volume, parathyroid hormone, acid-base balance, genetic disturbances such as Bartter's and Gitelman's syndromes, and diuretic action.

Original language	English (US)
Pages (from-to)	2-7
Number of pages	6
Journal	Nephron
Volume	81
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1159/000046292
State	Published - Jan 13 1999

Keywords

Amiloride
Calcium
Diuretics
Furosemide
Thiazide

ASJC Scopus subject areas

Physiology
Nephrology
Physiology (medical)
Urology

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AB - Ca absorption is mediated by both active and passive processes. Absorption in both proximal tubule and thick ascending limb is mainly coupled indirectly to Na absorption and is a passive process through the paracellular pathway. In the distal convoluted tubule, Ca absorption is regulated independently of Na absorption; this is the principal site of action of parathyroid hormone, calcitonin, and 1,25-(OH)2D3. Models for transport in proximal tubule, thick ascending limb, and distal convoluted tubule afford attractive explanations for the influence on Ca transport of effective arterial blood volume, parathyroid hormone, acid-base balance, genetic disturbances such as Bartter's and Gitelman's syndromes, and diuretic action.

KW - Amiloride

KW - Calcium

KW - Diuretics

KW - Furosemide

KW - Thiazide

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ER -

Renal handling of calcium

Abstract

Keywords

ASJC Scopus subject areas

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