TY - JOUR
T1 - Remnant-like particle cholesterol levels in patients with dysbetalipoproteinemia or coronary artery disease
AU - Devaraj, Sridevi
AU - Vega, Gloria L
AU - Lange, Rick
AU - Grundy, Scott M
AU - Jialal, Ishwarlal
N1 - Funding Information:
The authors greatly appreciate the financial support provided by Otsuka America Pharmaceuticals, USA, and gratefully acknowledge Elizabeth Thurston for manuscript preparation and Shaina Hirany for technical assistance.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/5
Y1 - 1998/5
N2 - PURPOSE: Several studies have provided support for a proatherogenic role for remnant lipoproteins. Thus, the aim of this study was to compare remnant- like particle (RLP) cholesterol levels in patients with coronary artery disease who were normolipidemic with those in controls of similar age and gender. We also assessed the usefulness of measuring RLP-cholesterol levels in patients with type III dyslipidemia. SUBJECTS AND METHODS: Remnant-like particle cholesterol levels were measured in 63 normolipidemic men with coronary artery disease and 23 male controls of similar age as well as in 15 patients with type III dyslipidemia and 103 controls, using an immunoaffinity method. RESULTS: Remnant-like particle cholesterol levels were significantly increased in men with coronary artery disease compared with controls (7.6 ± 3.8 mg/dL versus 5.7 ± 1.9 mg/dL, P <0.01). In patients with coronary artery disease, RLP-cholesterol levels were correlated with total triglyceride and nonhigh-density-lipoprotein (HDL) cholesterol levels, but not with HDL- cholesterol levels. RLP-cholesterol levels were significantly elevated in patients with type III dyslipidemia (median 119, range 31 to 240 mg/dL) compared with controls (median 5.6, range 2.2 to 10.5 mg/dL, P <0.001). CONCLUSION: Normolipidemic men with coronary artery disease have increased levels of RLP-cholesterol that is not detected with conventional lipid screening. The RLP-cholesterol assay is a simple method for detecting high concentrations of remnant lipoproteins in patients with type III dyslipidemia.
AB - PURPOSE: Several studies have provided support for a proatherogenic role for remnant lipoproteins. Thus, the aim of this study was to compare remnant- like particle (RLP) cholesterol levels in patients with coronary artery disease who were normolipidemic with those in controls of similar age and gender. We also assessed the usefulness of measuring RLP-cholesterol levels in patients with type III dyslipidemia. SUBJECTS AND METHODS: Remnant-like particle cholesterol levels were measured in 63 normolipidemic men with coronary artery disease and 23 male controls of similar age as well as in 15 patients with type III dyslipidemia and 103 controls, using an immunoaffinity method. RESULTS: Remnant-like particle cholesterol levels were significantly increased in men with coronary artery disease compared with controls (7.6 ± 3.8 mg/dL versus 5.7 ± 1.9 mg/dL, P <0.01). In patients with coronary artery disease, RLP-cholesterol levels were correlated with total triglyceride and nonhigh-density-lipoprotein (HDL) cholesterol levels, but not with HDL- cholesterol levels. RLP-cholesterol levels were significantly elevated in patients with type III dyslipidemia (median 119, range 31 to 240 mg/dL) compared with controls (median 5.6, range 2.2 to 10.5 mg/dL, P <0.001). CONCLUSION: Normolipidemic men with coronary artery disease have increased levels of RLP-cholesterol that is not detected with conventional lipid screening. The RLP-cholesterol assay is a simple method for detecting high concentrations of remnant lipoproteins in patients with type III dyslipidemia.
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U2 - 10.1016/S0002-9343(98)00089-8
DO - 10.1016/S0002-9343(98)00089-8
M3 - Article
C2 - 9626027
AN - SCOPUS:0032076553
SN - 0002-9343
VL - 104
SP - 445
EP - 450
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 5
ER -