@article{a702c1a055484373a0eca27eeaa7bcf8,
title = "Relationship between inflammatory biomarker galectin-3 and hippocampal volume in a community study",
abstract = "Galectin-3 (Gal3) is expressed by microglia and performs functions including adhesion; activation of macrophages and fibroblasts, and mediates inflammatory responses in the hippocampus. The present study examined whether serum Gal3 levels predict hippocampal volume in a multi-ethnic, community-based sample. Results of a multiple linear regression (controlling for depression, serum creatinine level, age, BMI, total brain volume, MoCA score, sex, ethnicity, smoking status, history of diabetes) showed that Gal3 levels significantly predicted left (p = .027) but not right hippocampal volume. The relationship was stronger in men than women. Findings suggest this novel inflammatory biomarker is associated with human hippocampal volume.",
keywords = "Dallas heart study, Galectin-3, Hippocampus, Memory, Neuroinflammation",
author = "Lowther, {Megan K.} and Tunnell, {Jarrod P.} and Palka, {Jayme M.} and King, {Darlene R.} and Salako, {Damilola C.} and Macris, {Dimitri G.} and Italiya, {Jay B.} and Grodin, {Justin L.} and North, {Carol S.} and Brown, {E. Sherwood}",
note = "Funding Information: Measurement of Galectin 3 was provided by Abbott Diagnostics. The project was supported in part by grant UL1TR001105 from the National Center for Advancing Translational Sciences , National Institutes of Health . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: Measurement of Galectin 3 was provided by Abbott Diagnostics. The project was supported in part by grant UL1TR001105 from the National Center for Advancing Translational Sciences, National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = nov,
day = "15",
doi = "10.1016/j.jneuroim.2020.577386",
language = "English (US)",
volume = "348",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
}